Androgen receptor and MYC equilibration centralizes on developmental super-enhancer

Androgen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of multiple genes including MYC, and supraphysiological androgen is effective in some patients. Here, we show that this repression is independent of AR chromatin binding and driven by coactivator redistribution, and...

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Detalles Bibliográficos
Autores principales: Guo, Haiyang, Wu, Yiming, Nouri, Mannan, Spisak, Sandor, Russo, Joshua W., Sowalsky, Adam G., Pomerantz, Mark M., Wei, Zhao, Korthauer, Keegan, Seo, Ji-Heui, Wang, Liyang, Arai, Seiji, Freedman, Matthew L., He, Housheng Hansen, Chen, Shaoyong, Balk, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674345/
https://www.ncbi.nlm.nih.gov/pubmed/34911936
http://dx.doi.org/10.1038/s41467-021-27077-y

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