Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α

Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and signals through a cytosolic kinase-endoribonuclease module. The endoribonuclease generates the transcription factor XBP1s by intron exc...

Descripción completa

Detalles Bibliográficos
Autores principales: Le Thomas, Adrien, Ferri, Elena, Marsters, Scot, Harnoss, Jonathan M., Lawrence, David A., Zuazo-Gaztelu, Iratxe, Modrusan, Zora, Chan, Sara, Solon, Margaret, Chalouni, Cécile, Li, Weihan, Koeppen, Hartmut, Rudolph, Joachim, Wang, Weiru, Wu, Thomas D., Walter, Peter, Ashkenazi, Avi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674358/
https://www.ncbi.nlm.nih.gov/pubmed/34911951
http://dx.doi.org/10.1038/s41467-021-27597-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674358/
https://www.ncbi.nlm.nih.gov/pubmed/34911951
http://dx.doi.org/10.1038/s41467-021-27597-7

Ejemplares similares