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Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α

Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and signals through a cytosolic kinase-endoribonuclease module. The endoribonuclease generates the transcription factor XBP1s by intron exc...

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Detalles Bibliográficos
Autores principales:	Le Thomas, Adrien, Ferri, Elena, Marsters, Scot, Harnoss, Jonathan M., Lawrence, David A., Zuazo-Gaztelu, Iratxe, Modrusan, Zora, Chan, Sara, Solon, Margaret, Chalouni, Cécile, Li, Weihan, Koeppen, Hartmut, Rudolph, Joachim, Wang, Weiru, Wu, Thomas D., Walter, Peter, Ashkenazi, Avi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674358/ https://www.ncbi.nlm.nih.gov/pubmed/34911951 http://dx.doi.org/10.1038/s41467-021-27597-7

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