PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT/ARNT homodimer formation

Aryl hydrocarbon receptor nuclear translocator (ARNT) mediates anti-fibrotic activity in kidney and liver through induction of ALK3-receptor expression and subsequently increased Smad1/5/8 signaling. While expression of ARNT can be pharmacologically induced by sub-immunosuppressive doses of FK506 or...

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Detalles Bibliográficos
Autores principales: Nyamsuren, Gunsmaa, Rapp, Gregor, Dihazi, Hassan, Zeisberg, Elisabeth M., Tampe, Desiree, Tampe, Björn, Zeisberg, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674365/
https://www.ncbi.nlm.nih.gov/pubmed/34912030
http://dx.doi.org/10.1038/s41598-021-03523-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674365/
https://www.ncbi.nlm.nih.gov/pubmed/34912030
http://dx.doi.org/10.1038/s41598-021-03523-1

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