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Study on Motion Management of Pancreatic Cancer Treated by CyberKnife
PURPOSE: We investigated the movement characteristics of pancreas and the clinical accuracy of tracking pancreas with the Synchrony Respiratory Tracking System (SRTS) during the CyberKnife treatment. These data provide a clinical data basis for the expansion margins of pancreatic tumor target. METHO...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674533/ https://www.ncbi.nlm.nih.gov/pubmed/34926273 http://dx.doi.org/10.3389/fonc.2021.767832 |
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author | Jing, Shenghua Jiang, Changchen Ji, Xiaoqin Qiu, Xiangnan Li, Jing Sun, Xiangdong Zhu, Xixu |
author_facet | Jing, Shenghua Jiang, Changchen Ji, Xiaoqin Qiu, Xiangnan Li, Jing Sun, Xiangdong Zhu, Xixu |
author_sort | Jing, Shenghua |
collection | PubMed |
description | PURPOSE: We investigated the movement characteristics of pancreas and the clinical accuracy of tracking pancreas with the Synchrony Respiratory Tracking System (SRTS) during the CyberKnife treatment. These data provide a clinical data basis for the expansion margins of pancreatic tumor target. METHODS AND MATERIALS: Forty-two patients with pancreatic cancer treated by CyberKnife were retrospectively studied. The pancreatic displacement calculated from the x-ray images collected during the time interval between two consecutive movements constituted a data set. RESULTS: The total mean motion amplitudes and standard deviations of pancreatic tumors in SI, LR, AP, and radial directions were 3.66 ± 1.71 mm, 0.97 ± 0.62 mm, 1.52 ± 1.02 mm, and 1.36 ± 0.49 mm, respectively. The overall mean correlation errors and standard deviations were 0.82 ± 0.46 mm, 0.47 ± 0.33 mm, 0.41 ± 0.24 mm, and 0.98 ± 0.37 mm, respectively. The overall mean prediction errors and standard deviations were 0.57 ± 0.14 mm, 0.62 ± 0.28 mm, 0.39 ± 0.17 mm, and 1.58 ± 0.36 mm, respectively. The correlation errors and prediction errors of pancreatic tumors at different anatomical positions in SI, LR, and AP directions were statistically significant (p < 0.05). CONCLUSIONS: The tumor motion amplitude, the tumor location, and the treatment time are the main factors affecting the tracking accuracy. The pancreatic tumors at different anatomical locations should be treated differently to ensure sufficient dose coverage of the pancreatic target area. |
format | Online Article Text |
id | pubmed-8674533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86745332021-12-17 Study on Motion Management of Pancreatic Cancer Treated by CyberKnife Jing, Shenghua Jiang, Changchen Ji, Xiaoqin Qiu, Xiangnan Li, Jing Sun, Xiangdong Zhu, Xixu Front Oncol Oncology PURPOSE: We investigated the movement characteristics of pancreas and the clinical accuracy of tracking pancreas with the Synchrony Respiratory Tracking System (SRTS) during the CyberKnife treatment. These data provide a clinical data basis for the expansion margins of pancreatic tumor target. METHODS AND MATERIALS: Forty-two patients with pancreatic cancer treated by CyberKnife were retrospectively studied. The pancreatic displacement calculated from the x-ray images collected during the time interval between two consecutive movements constituted a data set. RESULTS: The total mean motion amplitudes and standard deviations of pancreatic tumors in SI, LR, AP, and radial directions were 3.66 ± 1.71 mm, 0.97 ± 0.62 mm, 1.52 ± 1.02 mm, and 1.36 ± 0.49 mm, respectively. The overall mean correlation errors and standard deviations were 0.82 ± 0.46 mm, 0.47 ± 0.33 mm, 0.41 ± 0.24 mm, and 0.98 ± 0.37 mm, respectively. The overall mean prediction errors and standard deviations were 0.57 ± 0.14 mm, 0.62 ± 0.28 mm, 0.39 ± 0.17 mm, and 1.58 ± 0.36 mm, respectively. The correlation errors and prediction errors of pancreatic tumors at different anatomical positions in SI, LR, and AP directions were statistically significant (p < 0.05). CONCLUSIONS: The tumor motion amplitude, the tumor location, and the treatment time are the main factors affecting the tracking accuracy. The pancreatic tumors at different anatomical locations should be treated differently to ensure sufficient dose coverage of the pancreatic target area. Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8674533/ /pubmed/34926273 http://dx.doi.org/10.3389/fonc.2021.767832 Text en Copyright © 2021 Jing, Jiang, Ji, Qiu, Li, Sun and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Jing, Shenghua Jiang, Changchen Ji, Xiaoqin Qiu, Xiangnan Li, Jing Sun, Xiangdong Zhu, Xixu Study on Motion Management of Pancreatic Cancer Treated by CyberKnife |
title | Study on Motion Management of Pancreatic Cancer Treated by CyberKnife |
title_full | Study on Motion Management of Pancreatic Cancer Treated by CyberKnife |
title_fullStr | Study on Motion Management of Pancreatic Cancer Treated by CyberKnife |
title_full_unstemmed | Study on Motion Management of Pancreatic Cancer Treated by CyberKnife |
title_short | Study on Motion Management of Pancreatic Cancer Treated by CyberKnife |
title_sort | study on motion management of pancreatic cancer treated by cyberknife |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674533/ https://www.ncbi.nlm.nih.gov/pubmed/34926273 http://dx.doi.org/10.3389/fonc.2021.767832 |
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