The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a broad range of clinical responses including prominent microvascular damage. The capacity of SARS-CoV-2 to infect vascular cells is still debated. Additionally, the SARS-CoV-2 Spike (S) protein may act as a ligand to induce non...

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Detalles Bibliográficos
Autores principales: Avolio, Elisa, Carrabba, Michele, Milligan, Rachel, Kavanagh Williamson, Maia, Beltrami, Antonio P., Gupta, Kapil, Elvers, Karen T., Gamez, Monica, Foster, Rebecca R., Gillespie, Kathleen, Hamilton, Fergus, Arnold, David, Berger, Imre, Davidson, Andrew D., Hill, Darryl, Caputo, Massimo, Madeddu, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Cardiovascular System & Vascular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674568/
https://www.ncbi.nlm.nih.gov/pubmed/34807265
http://dx.doi.org/10.1042/CS20210735

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