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NOTCH alteration in EGFR-mutated lung adenocarcinoma leads to histological small-cell carcinoma transformation under EGFR-TKI treatment

BACKGROUND: Molecular targeted therapy has been developed as an innovative treatment for metastatic cancer. Epidermal growth factor receptor (EGFR) mutation is one of the most important and frequent oncogenic drivers in non-small-cell lung cancer, and EGFR-tyrosine kinase inhibitors are indispensabl...

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Detalles Bibliográficos
Autores principales:	Koba, Hayato, Kimura, Hideharu, Yoneda, Taro, Ogawa, Naohiko, Tanimura, Kota, Tambo, Yuichi, Sone, Takashi, Hosomichi, Kazuyoshi, Tajima, Atsushi, Kasahara, Kazuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674607/ https://www.ncbi.nlm.nih.gov/pubmed/35004247 http://dx.doi.org/10.21037/tlcr-21-536

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