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Pathogen-Host Interaction Repertoire at Proteome and Posttranslational Modification Levels During Fungal Infections

Prevalence of fungal diseases has increased globally in recent years, which often associated with increased immunocompromised patients, aging populations, and the novel Coronavirus pandemic. Furthermore, due to the limitation of available antifungal agents mortality and morbidity rates of invasion f...

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Autores principales: Li, Yanjian, Li, Hailong, Sun, Tianshu, Ding, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674643/
https://www.ncbi.nlm.nih.gov/pubmed/34926320
http://dx.doi.org/10.3389/fcimb.2021.774340
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author Li, Yanjian
Li, Hailong
Sun, Tianshu
Ding, Chen
author_facet Li, Yanjian
Li, Hailong
Sun, Tianshu
Ding, Chen
author_sort Li, Yanjian
collection PubMed
description Prevalence of fungal diseases has increased globally in recent years, which often associated with increased immunocompromised patients, aging populations, and the novel Coronavirus pandemic. Furthermore, due to the limitation of available antifungal agents mortality and morbidity rates of invasion fungal disease remain stubbornly high, and the emergence of multidrug-resistant fungi exacerbates the problem. Fungal pathogenicity and interactions between fungi and host have been the focus of many studies, as a result, lots of pathogenic mechanisms and fungal virulence factors have been identified. Mass spectrometry (MS)-based proteomics is a novel approach to better understand fungal pathogenicities and host–pathogen interactions at protein and protein posttranslational modification (PTM) levels. The approach has successfully elucidated interactions between pathogens and hosts by examining, for example, samples of fungal cells under different conditions, body fluids from infected patients, and exosomes. Many studies conclude that protein and PTM levels in both pathogens and hosts play important roles in progression of fungal diseases. This review summarizes mass spectrometry studies of protein and PTM levels from perspectives of both pathogens and hosts and provides an integrative conceptual outlook on fungal pathogenesis, antifungal agents development, and host–pathogen interactions.
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spelling pubmed-86746432021-12-17 Pathogen-Host Interaction Repertoire at Proteome and Posttranslational Modification Levels During Fungal Infections Li, Yanjian Li, Hailong Sun, Tianshu Ding, Chen Front Cell Infect Microbiol Cellular and Infection Microbiology Prevalence of fungal diseases has increased globally in recent years, which often associated with increased immunocompromised patients, aging populations, and the novel Coronavirus pandemic. Furthermore, due to the limitation of available antifungal agents mortality and morbidity rates of invasion fungal disease remain stubbornly high, and the emergence of multidrug-resistant fungi exacerbates the problem. Fungal pathogenicity and interactions between fungi and host have been the focus of many studies, as a result, lots of pathogenic mechanisms and fungal virulence factors have been identified. Mass spectrometry (MS)-based proteomics is a novel approach to better understand fungal pathogenicities and host–pathogen interactions at protein and protein posttranslational modification (PTM) levels. The approach has successfully elucidated interactions between pathogens and hosts by examining, for example, samples of fungal cells under different conditions, body fluids from infected patients, and exosomes. Many studies conclude that protein and PTM levels in both pathogens and hosts play important roles in progression of fungal diseases. This review summarizes mass spectrometry studies of protein and PTM levels from perspectives of both pathogens and hosts and provides an integrative conceptual outlook on fungal pathogenesis, antifungal agents development, and host–pathogen interactions. Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8674643/ /pubmed/34926320 http://dx.doi.org/10.3389/fcimb.2021.774340 Text en Copyright © 2021 Li, Li, Sun and Ding https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Li, Yanjian
Li, Hailong
Sun, Tianshu
Ding, Chen
Pathogen-Host Interaction Repertoire at Proteome and Posttranslational Modification Levels During Fungal Infections
title Pathogen-Host Interaction Repertoire at Proteome and Posttranslational Modification Levels During Fungal Infections
title_full Pathogen-Host Interaction Repertoire at Proteome and Posttranslational Modification Levels During Fungal Infections
title_fullStr Pathogen-Host Interaction Repertoire at Proteome and Posttranslational Modification Levels During Fungal Infections
title_full_unstemmed Pathogen-Host Interaction Repertoire at Proteome and Posttranslational Modification Levels During Fungal Infections
title_short Pathogen-Host Interaction Repertoire at Proteome and Posttranslational Modification Levels During Fungal Infections
title_sort pathogen-host interaction repertoire at proteome and posttranslational modification levels during fungal infections
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674643/
https://www.ncbi.nlm.nih.gov/pubmed/34926320
http://dx.doi.org/10.3389/fcimb.2021.774340
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