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Distinct Metagenomic Signatures in the SARS-CoV-2 Infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause gastrointestinal symptoms in the patients, but the role of gut microbiota in SARS-CoV-2 infection remains unclear. Thus, in this study, we aim to investigate whether SARS-CoV-2 infection affects the composition and func...

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Autores principales: Liu, Yijun, Zhang, Hongyang, Tang, Xiaojun, Jiang, Xuejun, Yan, Xiaojuan, Liu, Xizhao, Gong, Jiang, Mew, Kenley, Sun, Hao, Chen, Xiufeng, Zou, Zhen, Chen, Chengzhi, Qiu, Jingfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674698/
https://www.ncbi.nlm.nih.gov/pubmed/34926314
http://dx.doi.org/10.3389/fcimb.2021.706970
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author Liu, Yijun
Zhang, Hongyang
Tang, Xiaojun
Jiang, Xuejun
Yan, Xiaojuan
Liu, Xizhao
Gong, Jiang
Mew, Kenley
Sun, Hao
Chen, Xiufeng
Zou, Zhen
Chen, Chengzhi
Qiu, Jingfu
author_facet Liu, Yijun
Zhang, Hongyang
Tang, Xiaojun
Jiang, Xuejun
Yan, Xiaojuan
Liu, Xizhao
Gong, Jiang
Mew, Kenley
Sun, Hao
Chen, Xiufeng
Zou, Zhen
Chen, Chengzhi
Qiu, Jingfu
author_sort Liu, Yijun
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause gastrointestinal symptoms in the patients, but the role of gut microbiota in SARS-CoV-2 infection remains unclear. Thus, in this study, we aim to investigate whether SARS-CoV-2 infection affects the composition and function of gut microbiota. In this study, we demonstrated for the first time that significant shifts in microbiome composition and function were appeared in both SARS-CoV-2-infected asymptomatic and symptomatic cases. The relative abundance of Candidatus_Saccharibacteria was significantly increased, whereas the levels of Fibrobacteres was remarkably reduced in SARS-CoV-2-infected cases. There was one bacterial species, Spirochaetes displayed the difference between patients and asymptomatic cases. On the genus level, Tyzzerella was the key species that remarkably increased in both symptomatic and asymptomatic cases. Analyses of genome annotations further revealed SARS-CoV-2 infection resulted in the significant ‘functional dysbiosis’ of gut microbiota, including metabolic pathway, regulatory pathway and biosynthesis of secondary metabolites etc. We also identified potential metagenomic markers to discriminate SARS-CoV-2-infected symptomatic and asymptomatic cases from healthy controls. These findings together suggest gut microbiota is of possible etiological and diagnostic importance for SARS-CoV-2 infection.
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spelling pubmed-86746982021-12-17 Distinct Metagenomic Signatures in the SARS-CoV-2 Infection Liu, Yijun Zhang, Hongyang Tang, Xiaojun Jiang, Xuejun Yan, Xiaojuan Liu, Xizhao Gong, Jiang Mew, Kenley Sun, Hao Chen, Xiufeng Zou, Zhen Chen, Chengzhi Qiu, Jingfu Front Cell Infect Microbiol Cellular and Infection Microbiology Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause gastrointestinal symptoms in the patients, but the role of gut microbiota in SARS-CoV-2 infection remains unclear. Thus, in this study, we aim to investigate whether SARS-CoV-2 infection affects the composition and function of gut microbiota. In this study, we demonstrated for the first time that significant shifts in microbiome composition and function were appeared in both SARS-CoV-2-infected asymptomatic and symptomatic cases. The relative abundance of Candidatus_Saccharibacteria was significantly increased, whereas the levels of Fibrobacteres was remarkably reduced in SARS-CoV-2-infected cases. There was one bacterial species, Spirochaetes displayed the difference between patients and asymptomatic cases. On the genus level, Tyzzerella was the key species that remarkably increased in both symptomatic and asymptomatic cases. Analyses of genome annotations further revealed SARS-CoV-2 infection resulted in the significant ‘functional dysbiosis’ of gut microbiota, including metabolic pathway, regulatory pathway and biosynthesis of secondary metabolites etc. We also identified potential metagenomic markers to discriminate SARS-CoV-2-infected symptomatic and asymptomatic cases from healthy controls. These findings together suggest gut microbiota is of possible etiological and diagnostic importance for SARS-CoV-2 infection. Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8674698/ /pubmed/34926314 http://dx.doi.org/10.3389/fcimb.2021.706970 Text en Copyright © 2021 Liu, Zhang, Tang, Jiang, Yan, Liu, Gong, Mew, Sun, Chen, Zou, Chen and Qiu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Liu, Yijun
Zhang, Hongyang
Tang, Xiaojun
Jiang, Xuejun
Yan, Xiaojuan
Liu, Xizhao
Gong, Jiang
Mew, Kenley
Sun, Hao
Chen, Xiufeng
Zou, Zhen
Chen, Chengzhi
Qiu, Jingfu
Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
title Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
title_full Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
title_fullStr Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
title_full_unstemmed Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
title_short Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
title_sort distinct metagenomic signatures in the sars-cov-2 infection
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674698/
https://www.ncbi.nlm.nih.gov/pubmed/34926314
http://dx.doi.org/10.3389/fcimb.2021.706970
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