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Distinct Metagenomic Signatures in the SARS-CoV-2 Infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause gastrointestinal symptoms in the patients, but the role of gut microbiota in SARS-CoV-2 infection remains unclear. Thus, in this study, we aim to investigate whether SARS-CoV-2 infection affects the composition and func...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674698/ https://www.ncbi.nlm.nih.gov/pubmed/34926314 http://dx.doi.org/10.3389/fcimb.2021.706970 |
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author | Liu, Yijun Zhang, Hongyang Tang, Xiaojun Jiang, Xuejun Yan, Xiaojuan Liu, Xizhao Gong, Jiang Mew, Kenley Sun, Hao Chen, Xiufeng Zou, Zhen Chen, Chengzhi Qiu, Jingfu |
author_facet | Liu, Yijun Zhang, Hongyang Tang, Xiaojun Jiang, Xuejun Yan, Xiaojuan Liu, Xizhao Gong, Jiang Mew, Kenley Sun, Hao Chen, Xiufeng Zou, Zhen Chen, Chengzhi Qiu, Jingfu |
author_sort | Liu, Yijun |
collection | PubMed |
description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause gastrointestinal symptoms in the patients, but the role of gut microbiota in SARS-CoV-2 infection remains unclear. Thus, in this study, we aim to investigate whether SARS-CoV-2 infection affects the composition and function of gut microbiota. In this study, we demonstrated for the first time that significant shifts in microbiome composition and function were appeared in both SARS-CoV-2-infected asymptomatic and symptomatic cases. The relative abundance of Candidatus_Saccharibacteria was significantly increased, whereas the levels of Fibrobacteres was remarkably reduced in SARS-CoV-2-infected cases. There was one bacterial species, Spirochaetes displayed the difference between patients and asymptomatic cases. On the genus level, Tyzzerella was the key species that remarkably increased in both symptomatic and asymptomatic cases. Analyses of genome annotations further revealed SARS-CoV-2 infection resulted in the significant ‘functional dysbiosis’ of gut microbiota, including metabolic pathway, regulatory pathway and biosynthesis of secondary metabolites etc. We also identified potential metagenomic markers to discriminate SARS-CoV-2-infected symptomatic and asymptomatic cases from healthy controls. These findings together suggest gut microbiota is of possible etiological and diagnostic importance for SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-8674698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86746982021-12-17 Distinct Metagenomic Signatures in the SARS-CoV-2 Infection Liu, Yijun Zhang, Hongyang Tang, Xiaojun Jiang, Xuejun Yan, Xiaojuan Liu, Xizhao Gong, Jiang Mew, Kenley Sun, Hao Chen, Xiufeng Zou, Zhen Chen, Chengzhi Qiu, Jingfu Front Cell Infect Microbiol Cellular and Infection Microbiology Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause gastrointestinal symptoms in the patients, but the role of gut microbiota in SARS-CoV-2 infection remains unclear. Thus, in this study, we aim to investigate whether SARS-CoV-2 infection affects the composition and function of gut microbiota. In this study, we demonstrated for the first time that significant shifts in microbiome composition and function were appeared in both SARS-CoV-2-infected asymptomatic and symptomatic cases. The relative abundance of Candidatus_Saccharibacteria was significantly increased, whereas the levels of Fibrobacteres was remarkably reduced in SARS-CoV-2-infected cases. There was one bacterial species, Spirochaetes displayed the difference between patients and asymptomatic cases. On the genus level, Tyzzerella was the key species that remarkably increased in both symptomatic and asymptomatic cases. Analyses of genome annotations further revealed SARS-CoV-2 infection resulted in the significant ‘functional dysbiosis’ of gut microbiota, including metabolic pathway, regulatory pathway and biosynthesis of secondary metabolites etc. We also identified potential metagenomic markers to discriminate SARS-CoV-2-infected symptomatic and asymptomatic cases from healthy controls. These findings together suggest gut microbiota is of possible etiological and diagnostic importance for SARS-CoV-2 infection. Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8674698/ /pubmed/34926314 http://dx.doi.org/10.3389/fcimb.2021.706970 Text en Copyright © 2021 Liu, Zhang, Tang, Jiang, Yan, Liu, Gong, Mew, Sun, Chen, Zou, Chen and Qiu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Liu, Yijun Zhang, Hongyang Tang, Xiaojun Jiang, Xuejun Yan, Xiaojuan Liu, Xizhao Gong, Jiang Mew, Kenley Sun, Hao Chen, Xiufeng Zou, Zhen Chen, Chengzhi Qiu, Jingfu Distinct Metagenomic Signatures in the SARS-CoV-2 Infection |
title | Distinct Metagenomic Signatures in the SARS-CoV-2 Infection |
title_full | Distinct Metagenomic Signatures in the SARS-CoV-2 Infection |
title_fullStr | Distinct Metagenomic Signatures in the SARS-CoV-2 Infection |
title_full_unstemmed | Distinct Metagenomic Signatures in the SARS-CoV-2 Infection |
title_short | Distinct Metagenomic Signatures in the SARS-CoV-2 Infection |
title_sort | distinct metagenomic signatures in the sars-cov-2 infection |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674698/ https://www.ncbi.nlm.nih.gov/pubmed/34926314 http://dx.doi.org/10.3389/fcimb.2021.706970 |
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