Opioids in cancer: The κ-opioid receptor

The κ-opioid receptor (KOR) is one of the primary receptors of opioids and serves a vital role in the regulation of pain, anesthesia, addiction and other pathological and physiological processes. KOR is associated with several types of cancer and may influence cancer progression. It has been propose...

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Detalles Bibliográficos
Autores principales: Zhou, Qier, Zhang, Zhiwei, Long, Songkai, Li, Wanjun, Wang, Baiyun, Liang, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674701/
https://www.ncbi.nlm.nih.gov/pubmed/34878160
http://dx.doi.org/10.3892/mmr.2021.12560
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author Zhou, Qier
Zhang, Zhiwei
Long, Songkai
Li, Wanjun
Wang, Baiyun
Liang, Na
author_facet Zhou, Qier
Zhang, Zhiwei
Long, Songkai
Li, Wanjun
Wang, Baiyun
Liang, Na
author_sort Zhou, Qier
collection PubMed
description The κ-opioid receptor (KOR) is one of the primary receptors of opioids and serves a vital role in the regulation of pain, anesthesia, addiction and other pathological and physiological processes. KOR is associated with several types of cancer and may influence cancer progression. It has been proposed that KOR may represent a new tumor molecular marker and provide a novel basis for molecular targeted therapies for cancer. However, the association between KOR and cancer remains to be explored comprehensively. The present review introduces KOR and its association with different types of cancer. Improved understanding of KOR may facilitate development of novel antitumor therapies.
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spelling pubmed-86747012021-12-30 Opioids in cancer: The κ-opioid receptor Zhou, Qier Zhang, Zhiwei Long, Songkai Li, Wanjun Wang, Baiyun Liang, Na Mol Med Rep Review The κ-opioid receptor (KOR) is one of the primary receptors of opioids and serves a vital role in the regulation of pain, anesthesia, addiction and other pathological and physiological processes. KOR is associated with several types of cancer and may influence cancer progression. It has been proposed that KOR may represent a new tumor molecular marker and provide a novel basis for molecular targeted therapies for cancer. However, the association between KOR and cancer remains to be explored comprehensively. The present review introduces KOR and its association with different types of cancer. Improved understanding of KOR may facilitate development of novel antitumor therapies. D.A. Spandidos 2022-02 2021-12-08 /pmc/articles/PMC8674701/ /pubmed/34878160 http://dx.doi.org/10.3892/mmr.2021.12560 Text en Copyright: © Zhou et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Zhou, Qier
Zhang, Zhiwei
Long, Songkai
Li, Wanjun
Wang, Baiyun
Liang, Na
Opioids in cancer: The κ-opioid receptor
title Opioids in cancer: The κ-opioid receptor
title_full Opioids in cancer: The κ-opioid receptor
title_fullStr Opioids in cancer: The κ-opioid receptor
title_full_unstemmed Opioids in cancer: The κ-opioid receptor
title_short Opioids in cancer: The κ-opioid receptor
title_sort opioids in cancer: the κ-opioid receptor
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674701/
https://www.ncbi.nlm.nih.gov/pubmed/34878160
http://dx.doi.org/10.3892/mmr.2021.12560
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AT liwanjun opioidsincancerthekopioidreceptor
AT wangbaiyun opioidsincancerthekopioidreceptor
AT liangna opioidsincancerthekopioidreceptor

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