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Predicting persistence of hallucinations from childhood to adolescence
BACKGROUND: Psychotic experiences predict adverse health outcomes, particularly if they are persistent. However, it is unclear what distinguishes persistent from transient psychotic experiences. AIMS: In a large population-based cohort, we aimed to (a) describe the course of hallucinatory experience...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674728/ https://www.ncbi.nlm.nih.gov/pubmed/35048879 http://dx.doi.org/10.1192/bjp.2021.115 |
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author | Steenkamp, Lisa R. Tiemeier, Henning Blanken, Laura M. E. Hillegers, Manon H. J. Kushner, Steven A. Bolhuis, Koen |
author_facet | Steenkamp, Lisa R. Tiemeier, Henning Blanken, Laura M. E. Hillegers, Manon H. J. Kushner, Steven A. Bolhuis, Koen |
author_sort | Steenkamp, Lisa R. |
collection | PubMed |
description | BACKGROUND: Psychotic experiences predict adverse health outcomes, particularly if they are persistent. However, it is unclear what distinguishes persistent from transient psychotic experiences. AIMS: In a large population-based cohort, we aimed to (a) describe the course of hallucinatory experiences from childhood to adolescence, (b) compare characteristics of youth with persistent and remittent hallucinatory experiences, and (c) examine prediction models for persistence. METHOD: Youth were assessed longitudinally for hallucinatory experiences at mean ages of 10 and 14 years (n = 3473). Multi-informant-rated mental health problems, stressful life events, self-esteem, non-verbal IQ and parental psychopathology were examined in relation to absent, persistent, remittent and incident hallucinatory experiences. We evaluated two prediction models for persistence with logistic regression and assessed discrimination using the area under the curve (AUC). RESULTS: The persistence rate of hallucinatory experiences was 20.5%. Adolescents with persistent hallucinatory experiences had higher baseline levels of hallucinatory experiences, emotional and behavioural problems, as well as lower self-esteem and non-verbal IQ scores than youth with remittent hallucinatory experiences. Although the prediction model for persistence versus absence of hallucinatory experiences demonstrated excellent discriminatory power (AUC(-corrected) = 0.80), the prediction model for persistence versus remittance demonstrated poor accuracy (AUC(-corrected) = 0.61). CONCLUSIONS: This study provides support for the dynamic expression of childhood hallucinatory experiences and suggests increased neurodevelopmental vulnerability in youth with persistent hallucinatory experiences. Despite the inclusion of a wide array of psychosocial parameters, a prediction model discriminated poorly between youth with persistent versus remittent hallucinatory experiences, confirming that persistent hallucinatory experiences are a complex multifactorial trait. |
format | Online Article Text |
id | pubmed-8674728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-86747282021-12-16 Predicting persistence of hallucinations from childhood to adolescence Steenkamp, Lisa R. Tiemeier, Henning Blanken, Laura M. E. Hillegers, Manon H. J. Kushner, Steven A. Bolhuis, Koen Br J Psychiatry Paper BACKGROUND: Psychotic experiences predict adverse health outcomes, particularly if they are persistent. However, it is unclear what distinguishes persistent from transient psychotic experiences. AIMS: In a large population-based cohort, we aimed to (a) describe the course of hallucinatory experiences from childhood to adolescence, (b) compare characteristics of youth with persistent and remittent hallucinatory experiences, and (c) examine prediction models for persistence. METHOD: Youth were assessed longitudinally for hallucinatory experiences at mean ages of 10 and 14 years (n = 3473). Multi-informant-rated mental health problems, stressful life events, self-esteem, non-verbal IQ and parental psychopathology were examined in relation to absent, persistent, remittent and incident hallucinatory experiences. We evaluated two prediction models for persistence with logistic regression and assessed discrimination using the area under the curve (AUC). RESULTS: The persistence rate of hallucinatory experiences was 20.5%. Adolescents with persistent hallucinatory experiences had higher baseline levels of hallucinatory experiences, emotional and behavioural problems, as well as lower self-esteem and non-verbal IQ scores than youth with remittent hallucinatory experiences. Although the prediction model for persistence versus absence of hallucinatory experiences demonstrated excellent discriminatory power (AUC(-corrected) = 0.80), the prediction model for persistence versus remittance demonstrated poor accuracy (AUC(-corrected) = 0.61). CONCLUSIONS: This study provides support for the dynamic expression of childhood hallucinatory experiences and suggests increased neurodevelopmental vulnerability in youth with persistent hallucinatory experiences. Despite the inclusion of a wide array of psychosocial parameters, a prediction model discriminated poorly between youth with persistent versus remittent hallucinatory experiences, confirming that persistent hallucinatory experiences are a complex multifactorial trait. Cambridge University Press 2021-12 /pmc/articles/PMC8674728/ /pubmed/35048879 http://dx.doi.org/10.1192/bjp.2021.115 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Paper Steenkamp, Lisa R. Tiemeier, Henning Blanken, Laura M. E. Hillegers, Manon H. J. Kushner, Steven A. Bolhuis, Koen Predicting persistence of hallucinations from childhood to adolescence |
title | Predicting persistence of hallucinations from childhood to adolescence |
title_full | Predicting persistence of hallucinations from childhood to adolescence |
title_fullStr | Predicting persistence of hallucinations from childhood to adolescence |
title_full_unstemmed | Predicting persistence of hallucinations from childhood to adolescence |
title_short | Predicting persistence of hallucinations from childhood to adolescence |
title_sort | predicting persistence of hallucinations from childhood to adolescence |
topic | Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674728/ https://www.ncbi.nlm.nih.gov/pubmed/35048879 http://dx.doi.org/10.1192/bjp.2021.115 |
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