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The Emerging Biotherapeutic Agent: Akkermansia
The human gastrointestinal tract (GIT) is a well-recognized hub of microbial activities. The microbiota harboring the mucus layer of the GIT act as a defense against noxious substances, and pathogens including Clostridium difficile, Enterococcus faecium, Escherichia coli, Salmonella Typhimurium. Tox...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer India
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674859/ https://www.ncbi.nlm.nih.gov/pubmed/34931096 http://dx.doi.org/10.1007/s12088-021-00993-9 |
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author | Kalia, Vipin Chandra Gong, Chunjie Shanmugam, Ramasamy Lin, Hui Zhang, Liaoyuan Lee, Jung-Kul |
author_facet | Kalia, Vipin Chandra Gong, Chunjie Shanmugam, Ramasamy Lin, Hui Zhang, Liaoyuan Lee, Jung-Kul |
author_sort | Kalia, Vipin Chandra |
collection | PubMed |
description | The human gastrointestinal tract (GIT) is a well-recognized hub of microbial activities. The microbiota harboring the mucus layer of the GIT act as a defense against noxious substances, and pathogens including Clostridium difficile, Enterococcus faecium, Escherichia coli, Salmonella Typhimurium. Toxins, pathogens, and antibiotics perturb the commensal floral composition within the GIT. Imbalanced gut microbiota leads to dysbiosis, manifested as diseases ranging from obesity, diabetes, and cancer to reduced lifespan. Among the bacteria present in the gut microbiome, the most beneficial are those representing Firmicutes and Bacteroidetes. Recent studies have revealed the emergence of a novel biotherapeutic agent, Akkermansia, which is instrumental in regaining eubiosis and conferring various health benefits. |
format | Online Article Text |
id | pubmed-8674859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer India |
record_format | MEDLINE/PubMed |
spelling | pubmed-86748592021-12-16 The Emerging Biotherapeutic Agent: Akkermansia Kalia, Vipin Chandra Gong, Chunjie Shanmugam, Ramasamy Lin, Hui Zhang, Liaoyuan Lee, Jung-Kul Indian J Microbiol Review Article The human gastrointestinal tract (GIT) is a well-recognized hub of microbial activities. The microbiota harboring the mucus layer of the GIT act as a defense against noxious substances, and pathogens including Clostridium difficile, Enterococcus faecium, Escherichia coli, Salmonella Typhimurium. Toxins, pathogens, and antibiotics perturb the commensal floral composition within the GIT. Imbalanced gut microbiota leads to dysbiosis, manifested as diseases ranging from obesity, diabetes, and cancer to reduced lifespan. Among the bacteria present in the gut microbiome, the most beneficial are those representing Firmicutes and Bacteroidetes. Recent studies have revealed the emergence of a novel biotherapeutic agent, Akkermansia, which is instrumental in regaining eubiosis and conferring various health benefits. Springer India 2021-12-16 2022-03 /pmc/articles/PMC8674859/ /pubmed/34931096 http://dx.doi.org/10.1007/s12088-021-00993-9 Text en © Association of Microbiologists of India 2021 |
spellingShingle | Review Article Kalia, Vipin Chandra Gong, Chunjie Shanmugam, Ramasamy Lin, Hui Zhang, Liaoyuan Lee, Jung-Kul The Emerging Biotherapeutic Agent: Akkermansia |
title | The Emerging Biotherapeutic Agent: Akkermansia |
title_full | The Emerging Biotherapeutic Agent: Akkermansia |
title_fullStr | The Emerging Biotherapeutic Agent: Akkermansia |
title_full_unstemmed | The Emerging Biotherapeutic Agent: Akkermansia |
title_short | The Emerging Biotherapeutic Agent: Akkermansia |
title_sort | emerging biotherapeutic agent: akkermansia |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8674859/ https://www.ncbi.nlm.nih.gov/pubmed/34931096 http://dx.doi.org/10.1007/s12088-021-00993-9 |
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