Rapid characterization of spike variants via mammalian cell surface display

The SARS-CoV-2 spike protein is a critical component of vaccines and a target for neutralizing monoclonal antibodies (nAbs). Spike is also undergoing immunogenic selection with variants that increase infectivity and partially escape convalescent plasma. Here, we describe Spike Display, a high-throug...

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Detalles Bibliográficos
Autores principales: Javanmardi, Kamyab, Chou, Chia-Wei, Terrace, Cynthia I., Annapareddy, Ankur, Kaoud, Tamer S., Guo, Qingqing, Lutgens, Josh, Zorkic, Hayley, Horton, Andrew P., Gardner, Elizabeth C., Nguyen, Giaochau, Boutz, Daniel R., Goike, Jule, Voss, William N., Kuo, Hung-Che, Dalby, Kevin N., Gollihar, Jimmy D., Finkelstein, Ilya J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Technology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675084/
https://www.ncbi.nlm.nih.gov/pubmed/34919820
http://dx.doi.org/10.1016/j.molcel.2021.11.024

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