hnRNPA1/UP1 Unfolds KRAS G-Quadruplexes and Feeds a Regulatory Axis Controlling Gene Expression

[Image: see text] Recent studies have proven that the genetic landscape of pancreatic cancer is dominated by the KRAS oncogene. Its transcription is controlled by a G-rich motif (called 32R) located immediately upstream of the TSS. 32R may fold into a G-quadruplex (G4) in equilibrium between two G4...

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Detalles Bibliográficos
Autores principales: Ferino, Annalisa, Marquevielle, Julien, Choudhary, Himanshi, Cinque, Giorgio, Robert, Coralie, Bourdoncle, Anne, Picco, Raffaella, Mergny, Jean-Louis, Salgado, Gilmar F., Xodo, Luigi E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675163/
https://www.ncbi.nlm.nih.gov/pubmed/34926957
http://dx.doi.org/10.1021/acsomega.1c05538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675163/
https://www.ncbi.nlm.nih.gov/pubmed/34926957
http://dx.doi.org/10.1021/acsomega.1c05538

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