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Optimal control of the SIR model with constrained policy, with an application to COVID-19

This article considers the optimal control of the SIR model with both transmission and treatment uncertainty. It follows the model presented in Gatto and Schellhorn (2021). We make four significant improvements on the latter paper. First, we prove the existence of a solution to the model. Second, ou...

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Detalles Bibliográficos
Autores principales: Ding, Yujia, Schellhorn, Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675184/
https://www.ncbi.nlm.nih.gov/pubmed/34922976
http://dx.doi.org/10.1016/j.mbs.2021.108758
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author Ding, Yujia
Schellhorn, Henry
author_facet Ding, Yujia
Schellhorn, Henry
author_sort Ding, Yujia
collection PubMed
description This article considers the optimal control of the SIR model with both transmission and treatment uncertainty. It follows the model presented in Gatto and Schellhorn (2021). We make four significant improvements on the latter paper. First, we prove the existence of a solution to the model. Second, our interpretation of the control is more realistic: while in Gatto and Schellhorn (2021) the control [Formula: see text] is the proportion of the population that takes a basic dose of treatment, so that [Formula: see text] occurs only if some patients take more than a basic dose, in our paper, [Formula: see text] is constrained between zero and one, and represents thus the proportion of the population undergoing treatment. Third, we provide a complete solution for the moderate infection regime (with constant treatment). Finally, we give a thorough interpretation of the control in the moderate infection regime, while Gatto and Schellhorn (2021) focused on the interpretation of the low infection regime. Finally, we compare the efficiency of our control to curb the COVID-19 epidemic to other types of control.
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spelling pubmed-86751842021-12-17 Optimal control of the SIR model with constrained policy, with an application to COVID-19 Ding, Yujia Schellhorn, Henry Math Biosci Original Research Article This article considers the optimal control of the SIR model with both transmission and treatment uncertainty. It follows the model presented in Gatto and Schellhorn (2021). We make four significant improvements on the latter paper. First, we prove the existence of a solution to the model. Second, our interpretation of the control is more realistic: while in Gatto and Schellhorn (2021) the control [Formula: see text] is the proportion of the population that takes a basic dose of treatment, so that [Formula: see text] occurs only if some patients take more than a basic dose, in our paper, [Formula: see text] is constrained between zero and one, and represents thus the proportion of the population undergoing treatment. Third, we provide a complete solution for the moderate infection regime (with constant treatment). Finally, we give a thorough interpretation of the control in the moderate infection regime, while Gatto and Schellhorn (2021) focused on the interpretation of the low infection regime. Finally, we compare the efficiency of our control to curb the COVID-19 epidemic to other types of control. Elsevier Inc. 2022-02 2021-12-16 /pmc/articles/PMC8675184/ /pubmed/34922976 http://dx.doi.org/10.1016/j.mbs.2021.108758 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Research Article
Ding, Yujia
Schellhorn, Henry
Optimal control of the SIR model with constrained policy, with an application to COVID-19
title Optimal control of the SIR model with constrained policy, with an application to COVID-19
title_full Optimal control of the SIR model with constrained policy, with an application to COVID-19
title_fullStr Optimal control of the SIR model with constrained policy, with an application to COVID-19
title_full_unstemmed Optimal control of the SIR model with constrained policy, with an application to COVID-19
title_short Optimal control of the SIR model with constrained policy, with an application to COVID-19
title_sort optimal control of the sir model with constrained policy, with an application to covid-19
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675184/
https://www.ncbi.nlm.nih.gov/pubmed/34922976
http://dx.doi.org/10.1016/j.mbs.2021.108758
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