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Genomic attributes of homology-directed DNA repair deficiency in metastatic prostate cancer

Cancers with homology-directed DNA repair (HRR) deficiency exhibit high response rates to poly(ADP-ribose) polymerase inhibitors (PARPi) and platinum chemotherapy. Though mutations disrupting BRCA1 and BRCA2 associate with HRR deficiency (HRRd), patterns of genomic aberrations and mutation signature...

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Detalles Bibliográficos
Autores principales:	De Sarkar, Navonil, Dasgupta, Sayan, Chatterjee, Payel, Coleman, Ilsa, Ha, Gavin, Ang, Lisa S., Kohlbrenner, Emily A., Frank, Sander B., Nunez, Talina A., Salipante, Stephen J., Corey, Eva, Morrissey, Colm, Van Allen, Eliezer, Schweizer, Michael T., Haffner, Michael C., Patel, Radhika, Hanratty, Brian, Lucas, Jared M., Dumpit, Ruth F., Pritchard, Colin C., Montgomery, Robert B., Nelson, Peter S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675196/ https://www.ncbi.nlm.nih.gov/pubmed/34877933 http://dx.doi.org/10.1172/jci.insight.152789

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