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Identifying the temporal electrophysiological and molecular changes that contribute to TSC-associated epileptogenesis

Tuberous sclerosis complex (TSC), caused by heterozygous mutations in TSC1 or TSC2, frequently results in intractable epilepsy. Here, we made use of an inducible Tsc1-knockout mouse model, allowing us to study electrophysiological and molecular changes of Tsc1-induced epileptogenesis over time. We r...

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Detalles Bibliográficos
Autores principales:	Koene, Linda M.C., Niggl, Eva, Wallaard, Ilse, Proietti-Onori, Martina, Rotaru, Diana C., Elgersma, Ype
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675202/ https://www.ncbi.nlm.nih.gov/pubmed/34877936 http://dx.doi.org/10.1172/jci.insight.150120

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