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Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids
Medical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue organoids bridge the limitations of conventional 2D cell culture and animal models by recapitulating in vivo cellular complexity. Current 3D cardia...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675211/ https://www.ncbi.nlm.nih.gov/pubmed/34926467 http://dx.doi.org/10.3389/fcell.2021.788955 |
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author | Pang, Jeremy Kah Sheng Ho, Beatrice Xuan Chan, Woon-Khiong Soh, Boon-Seng |
author_facet | Pang, Jeremy Kah Sheng Ho, Beatrice Xuan Chan, Woon-Khiong Soh, Boon-Seng |
author_sort | Pang, Jeremy Kah Sheng |
collection | PubMed |
description | Medical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue organoids bridge the limitations of conventional 2D cell culture and animal models by recapitulating in vivo cellular complexity. Current 3D cardiac organoid cultures have shown their utility in modelling key developmental hallmarks of heart organogenesis, but the complexity of the organ demands a more versatile model that can investigate more fundamental parameters, such as structure, organization and compartmentalization of a functioning heart. This review will cover the prominence of cardiac organoids in recent research, unpack current in vitro 3D models of the developing heart and look into the prospect of developing physiologically appropriate cardiac organoids with translational applicability. In addition, we discuss some of the limitations of existing cardiac organoid models in modelling embryonic development of the heart and manifestation of cardiac diseases. |
format | Online Article Text |
id | pubmed-8675211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86752112021-12-17 Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids Pang, Jeremy Kah Sheng Ho, Beatrice Xuan Chan, Woon-Khiong Soh, Boon-Seng Front Cell Dev Biol Cell and Developmental Biology Medical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue organoids bridge the limitations of conventional 2D cell culture and animal models by recapitulating in vivo cellular complexity. Current 3D cardiac organoid cultures have shown their utility in modelling key developmental hallmarks of heart organogenesis, but the complexity of the organ demands a more versatile model that can investigate more fundamental parameters, such as structure, organization and compartmentalization of a functioning heart. This review will cover the prominence of cardiac organoids in recent research, unpack current in vitro 3D models of the developing heart and look into the prospect of developing physiologically appropriate cardiac organoids with translational applicability. In addition, we discuss some of the limitations of existing cardiac organoid models in modelling embryonic development of the heart and manifestation of cardiac diseases. Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8675211/ /pubmed/34926467 http://dx.doi.org/10.3389/fcell.2021.788955 Text en Copyright © 2021 Pang, Ho, Chan and Soh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Pang, Jeremy Kah Sheng Ho, Beatrice Xuan Chan, Woon-Khiong Soh, Boon-Seng Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids |
title | Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids |
title_full | Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids |
title_fullStr | Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids |
title_full_unstemmed | Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids |
title_short | Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids |
title_sort | insights to heart development and cardiac disease models using pluripotent stem cell derived 3d organoids |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675211/ https://www.ncbi.nlm.nih.gov/pubmed/34926467 http://dx.doi.org/10.3389/fcell.2021.788955 |
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