Ultrasmall PEI-Decorated Bi(2)Se(3) Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy

Bi-based nanomaterials, such as Bi(2)Se(3), play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall Bi(2)Se(3) nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). Bi(...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Peng, Wang, Lei, Chen, Xiuying, Li, Xiang, Yuan, Qinghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675356/
https://www.ncbi.nlm.nih.gov/pubmed/34925045
http://dx.doi.org/10.3389/fphar.2021.795012
_version_ 1784615857309089792
author Zhang, Peng
Wang, Lei
Chen, Xiuying
Li, Xiang
Yuan, Qinghai
author_facet Zhang, Peng
Wang, Lei
Chen, Xiuying
Li, Xiang
Yuan, Qinghai
author_sort Zhang, Peng
collection PubMed
description Bi-based nanomaterials, such as Bi(2)Se(3), play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall Bi(2)Se(3) nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). Bi(2)Se(3) nanodots exhibited superior CT imaging performance, and could be used as effective photothermal reagents owing to their broad absorption in the ultraviolet–visible–near infrared region. Under irradiation at 808 nm, PEI-Bi(2)Se(3) nanodots exhibited excellent photothermal-conversion efficiency of up to 41.3%. Good biocompatibility and significant tumor-ablation capabilities were demonstrated in vitro and in vivo. These results revealed that PEI-Bi(2)Se(3) nanodots are safe and a good nanotheranostic platform for CT imaging-guided PTT of cancer.
format Online
Article
Text
id pubmed-8675356
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86753562021-12-17 Ultrasmall PEI-Decorated Bi(2)Se(3) Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy Zhang, Peng Wang, Lei Chen, Xiuying Li, Xiang Yuan, Qinghai Front Pharmacol Pharmacology Bi-based nanomaterials, such as Bi(2)Se(3), play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall Bi(2)Se(3) nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). Bi(2)Se(3) nanodots exhibited superior CT imaging performance, and could be used as effective photothermal reagents owing to their broad absorption in the ultraviolet–visible–near infrared region. Under irradiation at 808 nm, PEI-Bi(2)Se(3) nanodots exhibited excellent photothermal-conversion efficiency of up to 41.3%. Good biocompatibility and significant tumor-ablation capabilities were demonstrated in vitro and in vivo. These results revealed that PEI-Bi(2)Se(3) nanodots are safe and a good nanotheranostic platform for CT imaging-guided PTT of cancer. Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8675356/ /pubmed/34925045 http://dx.doi.org/10.3389/fphar.2021.795012 Text en Copyright © 2021 Zhang, Wang, Chen, Li and Yuan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhang, Peng
Wang, Lei
Chen, Xiuying
Li, Xiang
Yuan, Qinghai
Ultrasmall PEI-Decorated Bi(2)Se(3) Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
title Ultrasmall PEI-Decorated Bi(2)Se(3) Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
title_full Ultrasmall PEI-Decorated Bi(2)Se(3) Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
title_fullStr Ultrasmall PEI-Decorated Bi(2)Se(3) Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
title_full_unstemmed Ultrasmall PEI-Decorated Bi(2)Se(3) Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
title_short Ultrasmall PEI-Decorated Bi(2)Se(3) Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy
title_sort ultrasmall pei-decorated bi(2)se(3) nanodots as a multifunctional theranostic nanoplatform for in vivo ct imaging-guided cancer photothermal therapy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675356/
https://www.ncbi.nlm.nih.gov/pubmed/34925045
http://dx.doi.org/10.3389/fphar.2021.795012
work_keys_str_mv AT zhangpeng ultrasmallpeidecoratedbi2se3nanodotsasamultifunctionaltheranosticnanoplatformforinvivoctimagingguidedcancerphotothermaltherapy
AT wanglei ultrasmallpeidecoratedbi2se3nanodotsasamultifunctionaltheranosticnanoplatformforinvivoctimagingguidedcancerphotothermaltherapy
AT chenxiuying ultrasmallpeidecoratedbi2se3nanodotsasamultifunctionaltheranosticnanoplatformforinvivoctimagingguidedcancerphotothermaltherapy
AT lixiang ultrasmallpeidecoratedbi2se3nanodotsasamultifunctionaltheranosticnanoplatformforinvivoctimagingguidedcancerphotothermaltherapy
AT yuanqinghai ultrasmallpeidecoratedbi2se3nanodotsasamultifunctionaltheranosticnanoplatformforinvivoctimagingguidedcancerphotothermaltherapy

Ejemplares similares