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Greater male than female variability in regional brain structure across the lifespan

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variabi...

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Autores principales: Wierenga, Lara M, Doucet, Gaelle E, Dima, Danai, Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N, Albajes‐Eizagirre, Anton, Alnæs, Dag, Alpert, Kathryn I, Andreassen, Ole A, Anticevic, Alan, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur‐Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, den Braber, Anouk, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K, Busatto, Geraldo F, Calhoun, Vince D, Canales‐Rodríguez, Erick J, Cannon, Dara M, Caseras, Xavier, Castellanos, Francisco X, Chaim‐Avancini, Tiffany M, Ching, Christopher RK, Clark, Vincent P, Conrod, Patricia J, Conzelmann, Annette, Crivello, Fabrice, Davey, Christopher G, Dickie, Erin W, Ehrlich, Stefan, van't Ent, Dennis, Fisher, Simon E, Fouche, Jean‐Paul, Franke, Barbara, Fuentes‐Claramonte, Paola, de Geus, Eco JC, Di Giorgio, Annabella, Glahn, David C, Gotlib, Ian H, Grabe, Hans J, Gruber, Oliver, Gruner, Patricia, Gur, Raquel E, Gur, Ruben C, Gurholt, Tiril P, de Haan, Lieuwe, Haatveit, Beathe, Harrison, Ben J, Hartman, Catharina A, Hatton, Sean N, Heslenfeld, Dirk J, van den Heuvel, Odile A, Hickie, Ian B, Hoekstra, Pieter J, Hohmann, Sarah, Holmes, Avram J, Hoogman, Martine, Hosten, Norbert, Howells, Fleur M, Hulshoff Pol, Hilleke E, Huyser, Chaim, Jahanshad, Neda, James, Anthony C, Jiang, Jiyang, Jönsson, Erik G, Joska, John A, Kalnin, Andrew J, Klein, Marieke, Koenders, Laura, Kolskår, Knut K, Krämer, Bernd, Kuntsi, Jonna, Lagopoulos, Jim, Lazaro, Luisa, Lebedeva, Irina S, Lee, Phil H, Lochner, Christine, Machielsen, Marise WJ, Maingault, Sophie, Martin, Nicholas G, Martínez‐Zalacaín, Ignacio, Mataix‐Cols, David, Mazoyer, Bernard, McDonald, Brenna C, McDonald, Colm, McIntosh, Andrew M, McMahon, Katie L, McPhilemy, Genevieve, van der Meer, Dennis, Menchón, José M, Naaijen, Jilly, Nyberg, Lars, Oosterlaan, Jaap, Paloyelis, Yannis, Pauli, Paul, Pergola, Giulio, Pomarol‐Clotet, Edith, Portella, Maria J, Radua, Joaquim, Reif, Andreas, Richard, Geneviève, Roffman, Joshua L, Rosa, Pedro GP, Sacchet, Matthew D, Sachdev, Perminder S, Salvador, Raymond, Sarró, Salvador, Satterthwaite, Theodore D, Saykin, Andrew J, Serpa, Mauricio H, Sim, Kang, Simmons, Andrew, Smoller, Jordan W, Sommer, Iris E, Soriano‐Mas, Carles, Stein, Dan J, Strike, Lachlan T, Szeszko, Philip R, Temmingh, Henk S, Thomopoulos, Sophia I, Tomyshev, Alexander S, Trollor, Julian N, Uhlmann, Anne, Veer, Ilya M, Veltman, Dick J, Voineskos, Aristotle, Völzke, Henry, Walter, Henrik, Wang, Lei, Wang, Yang, Weber, Bernd, Wen, Wei, West, John D, Westlye, Lars T, Whalley, Heather C, Williams, Steven CR, Wittfeld, Katharina, Wolf, Daniel H, Wright, Margaret J, Yoncheva, Yuliya N, Zanetti, Marcus V, Ziegler, Georg C, de Zubicaray, Greig I, Thompson, Paul M, Crone, Eveline A, Frangou, Sophia, Tamnes, Christian K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675415/
https://www.ncbi.nlm.nih.gov/pubmed/33044802
http://dx.doi.org/10.1002/hbm.25204
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author Wierenga, Lara M
Doucet, Gaelle E
Dima, Danai
Agartz, Ingrid
Aghajani, Moji
Akudjedu, Theophilus N
Albajes‐Eizagirre, Anton
Alnæs, Dag
Alpert, Kathryn I
Andreassen, Ole A
Anticevic, Alan
Asherson, Philip
Banaschewski, Tobias
Bargallo, Nuria
Baumeister, Sarah
Baur‐Streubel, Ramona
Bertolino, Alessandro
Bonvino, Aurora
Boomsma, Dorret I
Borgwardt, Stefan
Bourque, Josiane
den Braber, Anouk
Brandeis, Daniel
Breier, Alan
Brodaty, Henry
Brouwer, Rachel M
Buitelaar, Jan K
Busatto, Geraldo F
Calhoun, Vince D
Canales‐Rodríguez, Erick J
Cannon, Dara M
Caseras, Xavier
Castellanos, Francisco X
Chaim‐Avancini, Tiffany M
Ching, Christopher RK
Clark, Vincent P
Conrod, Patricia J
Conzelmann, Annette
Crivello, Fabrice
Davey, Christopher G
Dickie, Erin W
Ehrlich, Stefan
van't Ent, Dennis
Fisher, Simon E
Fouche, Jean‐Paul
Franke, Barbara
Fuentes‐Claramonte, Paola
de Geus, Eco JC
Di Giorgio, Annabella
Glahn, David C
Gotlib, Ian H
Grabe, Hans J
Gruber, Oliver
Gruner, Patricia
Gur, Raquel E
Gur, Ruben C
Gurholt, Tiril P
de Haan, Lieuwe
Haatveit, Beathe
Harrison, Ben J
Hartman, Catharina A
Hatton, Sean N
Heslenfeld, Dirk J
van den Heuvel, Odile A
Hickie, Ian B
Hoekstra, Pieter J
Hohmann, Sarah
Holmes, Avram J
Hoogman, Martine
Hosten, Norbert
Howells, Fleur M
Hulshoff Pol, Hilleke E
Huyser, Chaim
Jahanshad, Neda
James, Anthony C
Jiang, Jiyang
Jönsson, Erik G
Joska, John A
Kalnin, Andrew J
Klein, Marieke
Koenders, Laura
Kolskår, Knut K
Krämer, Bernd
Kuntsi, Jonna
Lagopoulos, Jim
Lazaro, Luisa
Lebedeva, Irina S
Lee, Phil H
Lochner, Christine
Machielsen, Marise WJ
Maingault, Sophie
Martin, Nicholas G
Martínez‐Zalacaín, Ignacio
Mataix‐Cols, David
Mazoyer, Bernard
McDonald, Brenna C
McDonald, Colm
McIntosh, Andrew M
McMahon, Katie L
McPhilemy, Genevieve
van der Meer, Dennis
Menchón, José M
Naaijen, Jilly
Nyberg, Lars
Oosterlaan, Jaap
Paloyelis, Yannis
Pauli, Paul
Pergola, Giulio
Pomarol‐Clotet, Edith
Portella, Maria J
Radua, Joaquim
Reif, Andreas
Richard, Geneviève
Roffman, Joshua L
Rosa, Pedro GP
Sacchet, Matthew D
Sachdev, Perminder S
Salvador, Raymond
Sarró, Salvador
Satterthwaite, Theodore D
Saykin, Andrew J
Serpa, Mauricio H
Sim, Kang
Simmons, Andrew
Smoller, Jordan W
Sommer, Iris E
Soriano‐Mas, Carles
Stein, Dan J
Strike, Lachlan T
Szeszko, Philip R
Temmingh, Henk S
Thomopoulos, Sophia I
Tomyshev, Alexander S
Trollor, Julian N
Uhlmann, Anne
Veer, Ilya M
Veltman, Dick J
Voineskos, Aristotle
Völzke, Henry
Walter, Henrik
Wang, Lei
Wang, Yang
Weber, Bernd
Wen, Wei
West, John D
Westlye, Lars T
Whalley, Heather C
Williams, Steven CR
Wittfeld, Katharina
Wolf, Daniel H
Wright, Margaret J
Yoncheva, Yuliya N
Zanetti, Marcus V
Ziegler, Georg C
de Zubicaray, Greig I
Thompson, Paul M
Crone, Eveline A
Frangou, Sophia
Tamnes, Christian K
author_facet Wierenga, Lara M
Doucet, Gaelle E
Dima, Danai
Agartz, Ingrid
Aghajani, Moji
Akudjedu, Theophilus N
Albajes‐Eizagirre, Anton
Alnæs, Dag
Alpert, Kathryn I
Andreassen, Ole A
Anticevic, Alan
Asherson, Philip
Banaschewski, Tobias
Bargallo, Nuria
Baumeister, Sarah
Baur‐Streubel, Ramona
Bertolino, Alessandro
Bonvino, Aurora
Boomsma, Dorret I
Borgwardt, Stefan
Bourque, Josiane
den Braber, Anouk
Brandeis, Daniel
Breier, Alan
Brodaty, Henry
Brouwer, Rachel M
Buitelaar, Jan K
Busatto, Geraldo F
Calhoun, Vince D
Canales‐Rodríguez, Erick J
Cannon, Dara M
Caseras, Xavier
Castellanos, Francisco X
Chaim‐Avancini, Tiffany M
Ching, Christopher RK
Clark, Vincent P
Conrod, Patricia J
Conzelmann, Annette
Crivello, Fabrice
Davey, Christopher G
Dickie, Erin W
Ehrlich, Stefan
van't Ent, Dennis
Fisher, Simon E
Fouche, Jean‐Paul
Franke, Barbara
Fuentes‐Claramonte, Paola
de Geus, Eco JC
Di Giorgio, Annabella
Glahn, David C
Gotlib, Ian H
Grabe, Hans J
Gruber, Oliver
Gruner, Patricia
Gur, Raquel E
Gur, Ruben C
Gurholt, Tiril P
de Haan, Lieuwe
Haatveit, Beathe
Harrison, Ben J
Hartman, Catharina A
Hatton, Sean N
Heslenfeld, Dirk J
van den Heuvel, Odile A
Hickie, Ian B
Hoekstra, Pieter J
Hohmann, Sarah
Holmes, Avram J
Hoogman, Martine
Hosten, Norbert
Howells, Fleur M
Hulshoff Pol, Hilleke E
Huyser, Chaim
Jahanshad, Neda
James, Anthony C
Jiang, Jiyang
Jönsson, Erik G
Joska, John A
Kalnin, Andrew J
Klein, Marieke
Koenders, Laura
Kolskår, Knut K
Krämer, Bernd
Kuntsi, Jonna
Lagopoulos, Jim
Lazaro, Luisa
Lebedeva, Irina S
Lee, Phil H
Lochner, Christine
Machielsen, Marise WJ
Maingault, Sophie
Martin, Nicholas G
Martínez‐Zalacaín, Ignacio
Mataix‐Cols, David
Mazoyer, Bernard
McDonald, Brenna C
McDonald, Colm
McIntosh, Andrew M
McMahon, Katie L
McPhilemy, Genevieve
van der Meer, Dennis
Menchón, José M
Naaijen, Jilly
Nyberg, Lars
Oosterlaan, Jaap
Paloyelis, Yannis
Pauli, Paul
Pergola, Giulio
Pomarol‐Clotet, Edith
Portella, Maria J
Radua, Joaquim
Reif, Andreas
Richard, Geneviève
Roffman, Joshua L
Rosa, Pedro GP
Sacchet, Matthew D
Sachdev, Perminder S
Salvador, Raymond
Sarró, Salvador
Satterthwaite, Theodore D
Saykin, Andrew J
Serpa, Mauricio H
Sim, Kang
Simmons, Andrew
Smoller, Jordan W
Sommer, Iris E
Soriano‐Mas, Carles
Stein, Dan J
Strike, Lachlan T
Szeszko, Philip R
Temmingh, Henk S
Thomopoulos, Sophia I
Tomyshev, Alexander S
Trollor, Julian N
Uhlmann, Anne
Veer, Ilya M
Veltman, Dick J
Voineskos, Aristotle
Völzke, Henry
Walter, Henrik
Wang, Lei
Wang, Yang
Weber, Bernd
Wen, Wei
West, John D
Westlye, Lars T
Whalley, Heather C
Williams, Steven CR
Wittfeld, Katharina
Wolf, Daniel H
Wright, Margaret J
Yoncheva, Yuliya N
Zanetti, Marcus V
Ziegler, Georg C
de Zubicaray, Greig I
Thompson, Paul M
Crone, Eveline A
Frangou, Sophia
Tamnes, Christian K
author_sort Wierenga, Lara M
collection PubMed
description For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1‐90 years old (47% females). We observed significant patterns of greater male than female between‐subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene‐environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex‐specific vulnerability to disorders.
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spelling pubmed-86754152021-12-27 Greater male than female variability in regional brain structure across the lifespan Wierenga, Lara M Doucet, Gaelle E Dima, Danai Agartz, Ingrid Aghajani, Moji Akudjedu, Theophilus N Albajes‐Eizagirre, Anton Alnæs, Dag Alpert, Kathryn I Andreassen, Ole A Anticevic, Alan Asherson, Philip Banaschewski, Tobias Bargallo, Nuria Baumeister, Sarah Baur‐Streubel, Ramona Bertolino, Alessandro Bonvino, Aurora Boomsma, Dorret I Borgwardt, Stefan Bourque, Josiane den Braber, Anouk Brandeis, Daniel Breier, Alan Brodaty, Henry Brouwer, Rachel M Buitelaar, Jan K Busatto, Geraldo F Calhoun, Vince D Canales‐Rodríguez, Erick J Cannon, Dara M Caseras, Xavier Castellanos, Francisco X Chaim‐Avancini, Tiffany M Ching, Christopher RK Clark, Vincent P Conrod, Patricia J Conzelmann, Annette Crivello, Fabrice Davey, Christopher G Dickie, Erin W Ehrlich, Stefan van't Ent, Dennis Fisher, Simon E Fouche, Jean‐Paul Franke, Barbara Fuentes‐Claramonte, Paola de Geus, Eco JC Di Giorgio, Annabella Glahn, David C Gotlib, Ian H Grabe, Hans J Gruber, Oliver Gruner, Patricia Gur, Raquel E Gur, Ruben C Gurholt, Tiril P de Haan, Lieuwe Haatveit, Beathe Harrison, Ben J Hartman, Catharina A Hatton, Sean N Heslenfeld, Dirk J van den Heuvel, Odile A Hickie, Ian B Hoekstra, Pieter J Hohmann, Sarah Holmes, Avram J Hoogman, Martine Hosten, Norbert Howells, Fleur M Hulshoff Pol, Hilleke E Huyser, Chaim Jahanshad, Neda James, Anthony C Jiang, Jiyang Jönsson, Erik G Joska, John A Kalnin, Andrew J Klein, Marieke Koenders, Laura Kolskår, Knut K Krämer, Bernd Kuntsi, Jonna Lagopoulos, Jim Lazaro, Luisa Lebedeva, Irina S Lee, Phil H Lochner, Christine Machielsen, Marise WJ Maingault, Sophie Martin, Nicholas G Martínez‐Zalacaín, Ignacio Mataix‐Cols, David Mazoyer, Bernard McDonald, Brenna C McDonald, Colm McIntosh, Andrew M McMahon, Katie L McPhilemy, Genevieve van der Meer, Dennis Menchón, José M Naaijen, Jilly Nyberg, Lars Oosterlaan, Jaap Paloyelis, Yannis Pauli, Paul Pergola, Giulio Pomarol‐Clotet, Edith Portella, Maria J Radua, Joaquim Reif, Andreas Richard, Geneviève Roffman, Joshua L Rosa, Pedro GP Sacchet, Matthew D Sachdev, Perminder S Salvador, Raymond Sarró, Salvador Satterthwaite, Theodore D Saykin, Andrew J Serpa, Mauricio H Sim, Kang Simmons, Andrew Smoller, Jordan W Sommer, Iris E Soriano‐Mas, Carles Stein, Dan J Strike, Lachlan T Szeszko, Philip R Temmingh, Henk S Thomopoulos, Sophia I Tomyshev, Alexander S Trollor, Julian N Uhlmann, Anne Veer, Ilya M Veltman, Dick J Voineskos, Aristotle Völzke, Henry Walter, Henrik Wang, Lei Wang, Yang Weber, Bernd Wen, Wei West, John D Westlye, Lars T Whalley, Heather C Williams, Steven CR Wittfeld, Katharina Wolf, Daniel H Wright, Margaret J Yoncheva, Yuliya N Zanetti, Marcus V Ziegler, Georg C de Zubicaray, Greig I Thompson, Paul M Crone, Eveline A Frangou, Sophia Tamnes, Christian K Hum Brain Mapp Research Articles For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1‐90 years old (47% females). We observed significant patterns of greater male than female between‐subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene‐environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex‐specific vulnerability to disorders. John Wiley & Sons, Inc. 2020-10-12 /pmc/articles/PMC8675415/ /pubmed/33044802 http://dx.doi.org/10.1002/hbm.25204 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Wierenga, Lara M
Doucet, Gaelle E
Dima, Danai
Agartz, Ingrid
Aghajani, Moji
Akudjedu, Theophilus N
Albajes‐Eizagirre, Anton
Alnæs, Dag
Alpert, Kathryn I
Andreassen, Ole A
Anticevic, Alan
Asherson, Philip
Banaschewski, Tobias
Bargallo, Nuria
Baumeister, Sarah
Baur‐Streubel, Ramona
Bertolino, Alessandro
Bonvino, Aurora
Boomsma, Dorret I
Borgwardt, Stefan
Bourque, Josiane
den Braber, Anouk
Brandeis, Daniel
Breier, Alan
Brodaty, Henry
Brouwer, Rachel M
Buitelaar, Jan K
Busatto, Geraldo F
Calhoun, Vince D
Canales‐Rodríguez, Erick J
Cannon, Dara M
Caseras, Xavier
Castellanos, Francisco X
Chaim‐Avancini, Tiffany M
Ching, Christopher RK
Clark, Vincent P
Conrod, Patricia J
Conzelmann, Annette
Crivello, Fabrice
Davey, Christopher G
Dickie, Erin W
Ehrlich, Stefan
van't Ent, Dennis
Fisher, Simon E
Fouche, Jean‐Paul
Franke, Barbara
Fuentes‐Claramonte, Paola
de Geus, Eco JC
Di Giorgio, Annabella
Glahn, David C
Gotlib, Ian H
Grabe, Hans J
Gruber, Oliver
Gruner, Patricia
Gur, Raquel E
Gur, Ruben C
Gurholt, Tiril P
de Haan, Lieuwe
Haatveit, Beathe
Harrison, Ben J
Hartman, Catharina A
Hatton, Sean N
Heslenfeld, Dirk J
van den Heuvel, Odile A
Hickie, Ian B
Hoekstra, Pieter J
Hohmann, Sarah
Holmes, Avram J
Hoogman, Martine
Hosten, Norbert
Howells, Fleur M
Hulshoff Pol, Hilleke E
Huyser, Chaim
Jahanshad, Neda
James, Anthony C
Jiang, Jiyang
Jönsson, Erik G
Joska, John A
Kalnin, Andrew J
Klein, Marieke
Koenders, Laura
Kolskår, Knut K
Krämer, Bernd
Kuntsi, Jonna
Lagopoulos, Jim
Lazaro, Luisa
Lebedeva, Irina S
Lee, Phil H
Lochner, Christine
Machielsen, Marise WJ
Maingault, Sophie
Martin, Nicholas G
Martínez‐Zalacaín, Ignacio
Mataix‐Cols, David
Mazoyer, Bernard
McDonald, Brenna C
McDonald, Colm
McIntosh, Andrew M
McMahon, Katie L
McPhilemy, Genevieve
van der Meer, Dennis
Menchón, José M
Naaijen, Jilly
Nyberg, Lars
Oosterlaan, Jaap
Paloyelis, Yannis
Pauli, Paul
Pergola, Giulio
Pomarol‐Clotet, Edith
Portella, Maria J
Radua, Joaquim
Reif, Andreas
Richard, Geneviève
Roffman, Joshua L
Rosa, Pedro GP
Sacchet, Matthew D
Sachdev, Perminder S
Salvador, Raymond
Sarró, Salvador
Satterthwaite, Theodore D
Saykin, Andrew J
Serpa, Mauricio H
Sim, Kang
Simmons, Andrew
Smoller, Jordan W
Sommer, Iris E
Soriano‐Mas, Carles
Stein, Dan J
Strike, Lachlan T
Szeszko, Philip R
Temmingh, Henk S
Thomopoulos, Sophia I
Tomyshev, Alexander S
Trollor, Julian N
Uhlmann, Anne
Veer, Ilya M
Veltman, Dick J
Voineskos, Aristotle
Völzke, Henry
Walter, Henrik
Wang, Lei
Wang, Yang
Weber, Bernd
Wen, Wei
West, John D
Westlye, Lars T
Whalley, Heather C
Williams, Steven CR
Wittfeld, Katharina
Wolf, Daniel H
Wright, Margaret J
Yoncheva, Yuliya N
Zanetti, Marcus V
Ziegler, Georg C
de Zubicaray, Greig I
Thompson, Paul M
Crone, Eveline A
Frangou, Sophia
Tamnes, Christian K
Greater male than female variability in regional brain structure across the lifespan
title Greater male than female variability in regional brain structure across the lifespan
title_full Greater male than female variability in regional brain structure across the lifespan
title_fullStr Greater male than female variability in regional brain structure across the lifespan
title_full_unstemmed Greater male than female variability in regional brain structure across the lifespan
title_short Greater male than female variability in regional brain structure across the lifespan
title_sort greater male than female variability in regional brain structure across the lifespan
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675415/
https://www.ncbi.nlm.nih.gov/pubmed/33044802
http://dx.doi.org/10.1002/hbm.25204
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