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Greater male than female variability in regional brain structure across the lifespan
For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variabi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675415/ https://www.ncbi.nlm.nih.gov/pubmed/33044802 http://dx.doi.org/10.1002/hbm.25204 |
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author | Wierenga, Lara M Doucet, Gaelle E Dima, Danai Agartz, Ingrid Aghajani, Moji Akudjedu, Theophilus N Albajes‐Eizagirre, Anton Alnæs, Dag Alpert, Kathryn I Andreassen, Ole A Anticevic, Alan Asherson, Philip Banaschewski, Tobias Bargallo, Nuria Baumeister, Sarah Baur‐Streubel, Ramona Bertolino, Alessandro Bonvino, Aurora Boomsma, Dorret I Borgwardt, Stefan Bourque, Josiane den Braber, Anouk Brandeis, Daniel Breier, Alan Brodaty, Henry Brouwer, Rachel M Buitelaar, Jan K Busatto, Geraldo F Calhoun, Vince D Canales‐Rodríguez, Erick J Cannon, Dara M Caseras, Xavier Castellanos, Francisco X Chaim‐Avancini, Tiffany M Ching, Christopher RK Clark, Vincent P Conrod, Patricia J Conzelmann, Annette Crivello, Fabrice Davey, Christopher G Dickie, Erin W Ehrlich, Stefan van't Ent, Dennis Fisher, Simon E Fouche, Jean‐Paul Franke, Barbara Fuentes‐Claramonte, Paola de Geus, Eco JC Di Giorgio, Annabella Glahn, David C Gotlib, Ian H Grabe, Hans J Gruber, Oliver Gruner, Patricia Gur, Raquel E Gur, Ruben C Gurholt, Tiril P de Haan, Lieuwe Haatveit, Beathe Harrison, Ben J Hartman, Catharina A Hatton, Sean N Heslenfeld, Dirk J van den Heuvel, Odile A Hickie, Ian B Hoekstra, Pieter J Hohmann, Sarah Holmes, Avram J Hoogman, Martine Hosten, Norbert Howells, Fleur M Hulshoff Pol, Hilleke E Huyser, Chaim Jahanshad, Neda James, Anthony C Jiang, Jiyang Jönsson, Erik G Joska, John A Kalnin, Andrew J Klein, Marieke Koenders, Laura Kolskår, Knut K Krämer, Bernd Kuntsi, Jonna Lagopoulos, Jim Lazaro, Luisa Lebedeva, Irina S Lee, Phil H Lochner, Christine Machielsen, Marise WJ Maingault, Sophie Martin, Nicholas G Martínez‐Zalacaín, Ignacio Mataix‐Cols, David Mazoyer, Bernard McDonald, Brenna C McDonald, Colm McIntosh, Andrew M McMahon, Katie L McPhilemy, Genevieve van der Meer, Dennis Menchón, José M Naaijen, Jilly Nyberg, Lars Oosterlaan, Jaap Paloyelis, Yannis Pauli, Paul Pergola, Giulio Pomarol‐Clotet, Edith Portella, Maria J Radua, Joaquim Reif, Andreas Richard, Geneviève Roffman, Joshua L Rosa, Pedro GP Sacchet, Matthew D Sachdev, Perminder S Salvador, Raymond Sarró, Salvador Satterthwaite, Theodore D Saykin, Andrew J Serpa, Mauricio H Sim, Kang Simmons, Andrew Smoller, Jordan W Sommer, Iris E Soriano‐Mas, Carles Stein, Dan J Strike, Lachlan T Szeszko, Philip R Temmingh, Henk S Thomopoulos, Sophia I Tomyshev, Alexander S Trollor, Julian N Uhlmann, Anne Veer, Ilya M Veltman, Dick J Voineskos, Aristotle Völzke, Henry Walter, Henrik Wang, Lei Wang, Yang Weber, Bernd Wen, Wei West, John D Westlye, Lars T Whalley, Heather C Williams, Steven CR Wittfeld, Katharina Wolf, Daniel H Wright, Margaret J Yoncheva, Yuliya N Zanetti, Marcus V Ziegler, Georg C de Zubicaray, Greig I Thompson, Paul M Crone, Eveline A Frangou, Sophia Tamnes, Christian K |
author_facet | Wierenga, Lara M Doucet, Gaelle E Dima, Danai Agartz, Ingrid Aghajani, Moji Akudjedu, Theophilus N Albajes‐Eizagirre, Anton Alnæs, Dag Alpert, Kathryn I Andreassen, Ole A Anticevic, Alan Asherson, Philip Banaschewski, Tobias Bargallo, Nuria Baumeister, Sarah Baur‐Streubel, Ramona Bertolino, Alessandro Bonvino, Aurora Boomsma, Dorret I Borgwardt, Stefan Bourque, Josiane den Braber, Anouk Brandeis, Daniel Breier, Alan Brodaty, Henry Brouwer, Rachel M Buitelaar, Jan K Busatto, Geraldo F Calhoun, Vince D Canales‐Rodríguez, Erick J Cannon, Dara M Caseras, Xavier Castellanos, Francisco X Chaim‐Avancini, Tiffany M Ching, Christopher RK Clark, Vincent P Conrod, Patricia J Conzelmann, Annette Crivello, Fabrice Davey, Christopher G Dickie, Erin W Ehrlich, Stefan van't Ent, Dennis Fisher, Simon E Fouche, Jean‐Paul Franke, Barbara Fuentes‐Claramonte, Paola de Geus, Eco JC Di Giorgio, Annabella Glahn, David C Gotlib, Ian H Grabe, Hans J Gruber, Oliver Gruner, Patricia Gur, Raquel E Gur, Ruben C Gurholt, Tiril P de Haan, Lieuwe Haatveit, Beathe Harrison, Ben J Hartman, Catharina A Hatton, Sean N Heslenfeld, Dirk J van den Heuvel, Odile A Hickie, Ian B Hoekstra, Pieter J Hohmann, Sarah Holmes, Avram J Hoogman, Martine Hosten, Norbert Howells, Fleur M Hulshoff Pol, Hilleke E Huyser, Chaim Jahanshad, Neda James, Anthony C Jiang, Jiyang Jönsson, Erik G Joska, John A Kalnin, Andrew J Klein, Marieke Koenders, Laura Kolskår, Knut K Krämer, Bernd Kuntsi, Jonna Lagopoulos, Jim Lazaro, Luisa Lebedeva, Irina S Lee, Phil H Lochner, Christine Machielsen, Marise WJ Maingault, Sophie Martin, Nicholas G Martínez‐Zalacaín, Ignacio Mataix‐Cols, David Mazoyer, Bernard McDonald, Brenna C McDonald, Colm McIntosh, Andrew M McMahon, Katie L McPhilemy, Genevieve van der Meer, Dennis Menchón, José M Naaijen, Jilly Nyberg, Lars Oosterlaan, Jaap Paloyelis, Yannis Pauli, Paul Pergola, Giulio Pomarol‐Clotet, Edith Portella, Maria J Radua, Joaquim Reif, Andreas Richard, Geneviève Roffman, Joshua L Rosa, Pedro GP Sacchet, Matthew D Sachdev, Perminder S Salvador, Raymond Sarró, Salvador Satterthwaite, Theodore D Saykin, Andrew J Serpa, Mauricio H Sim, Kang Simmons, Andrew Smoller, Jordan W Sommer, Iris E Soriano‐Mas, Carles Stein, Dan J Strike, Lachlan T Szeszko, Philip R Temmingh, Henk S Thomopoulos, Sophia I Tomyshev, Alexander S Trollor, Julian N Uhlmann, Anne Veer, Ilya M Veltman, Dick J Voineskos, Aristotle Völzke, Henry Walter, Henrik Wang, Lei Wang, Yang Weber, Bernd Wen, Wei West, John D Westlye, Lars T Whalley, Heather C Williams, Steven CR Wittfeld, Katharina Wolf, Daniel H Wright, Margaret J Yoncheva, Yuliya N Zanetti, Marcus V Ziegler, Georg C de Zubicaray, Greig I Thompson, Paul M Crone, Eveline A Frangou, Sophia Tamnes, Christian K |
author_sort | Wierenga, Lara M |
collection | PubMed |
description | For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1‐90 years old (47% females). We observed significant patterns of greater male than female between‐subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene‐environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex‐specific vulnerability to disorders. |
format | Online Article Text |
id | pubmed-8675415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86754152021-12-27 Greater male than female variability in regional brain structure across the lifespan Wierenga, Lara M Doucet, Gaelle E Dima, Danai Agartz, Ingrid Aghajani, Moji Akudjedu, Theophilus N Albajes‐Eizagirre, Anton Alnæs, Dag Alpert, Kathryn I Andreassen, Ole A Anticevic, Alan Asherson, Philip Banaschewski, Tobias Bargallo, Nuria Baumeister, Sarah Baur‐Streubel, Ramona Bertolino, Alessandro Bonvino, Aurora Boomsma, Dorret I Borgwardt, Stefan Bourque, Josiane den Braber, Anouk Brandeis, Daniel Breier, Alan Brodaty, Henry Brouwer, Rachel M Buitelaar, Jan K Busatto, Geraldo F Calhoun, Vince D Canales‐Rodríguez, Erick J Cannon, Dara M Caseras, Xavier Castellanos, Francisco X Chaim‐Avancini, Tiffany M Ching, Christopher RK Clark, Vincent P Conrod, Patricia J Conzelmann, Annette Crivello, Fabrice Davey, Christopher G Dickie, Erin W Ehrlich, Stefan van't Ent, Dennis Fisher, Simon E Fouche, Jean‐Paul Franke, Barbara Fuentes‐Claramonte, Paola de Geus, Eco JC Di Giorgio, Annabella Glahn, David C Gotlib, Ian H Grabe, Hans J Gruber, Oliver Gruner, Patricia Gur, Raquel E Gur, Ruben C Gurholt, Tiril P de Haan, Lieuwe Haatveit, Beathe Harrison, Ben J Hartman, Catharina A Hatton, Sean N Heslenfeld, Dirk J van den Heuvel, Odile A Hickie, Ian B Hoekstra, Pieter J Hohmann, Sarah Holmes, Avram J Hoogman, Martine Hosten, Norbert Howells, Fleur M Hulshoff Pol, Hilleke E Huyser, Chaim Jahanshad, Neda James, Anthony C Jiang, Jiyang Jönsson, Erik G Joska, John A Kalnin, Andrew J Klein, Marieke Koenders, Laura Kolskår, Knut K Krämer, Bernd Kuntsi, Jonna Lagopoulos, Jim Lazaro, Luisa Lebedeva, Irina S Lee, Phil H Lochner, Christine Machielsen, Marise WJ Maingault, Sophie Martin, Nicholas G Martínez‐Zalacaín, Ignacio Mataix‐Cols, David Mazoyer, Bernard McDonald, Brenna C McDonald, Colm McIntosh, Andrew M McMahon, Katie L McPhilemy, Genevieve van der Meer, Dennis Menchón, José M Naaijen, Jilly Nyberg, Lars Oosterlaan, Jaap Paloyelis, Yannis Pauli, Paul Pergola, Giulio Pomarol‐Clotet, Edith Portella, Maria J Radua, Joaquim Reif, Andreas Richard, Geneviève Roffman, Joshua L Rosa, Pedro GP Sacchet, Matthew D Sachdev, Perminder S Salvador, Raymond Sarró, Salvador Satterthwaite, Theodore D Saykin, Andrew J Serpa, Mauricio H Sim, Kang Simmons, Andrew Smoller, Jordan W Sommer, Iris E Soriano‐Mas, Carles Stein, Dan J Strike, Lachlan T Szeszko, Philip R Temmingh, Henk S Thomopoulos, Sophia I Tomyshev, Alexander S Trollor, Julian N Uhlmann, Anne Veer, Ilya M Veltman, Dick J Voineskos, Aristotle Völzke, Henry Walter, Henrik Wang, Lei Wang, Yang Weber, Bernd Wen, Wei West, John D Westlye, Lars T Whalley, Heather C Williams, Steven CR Wittfeld, Katharina Wolf, Daniel H Wright, Margaret J Yoncheva, Yuliya N Zanetti, Marcus V Ziegler, Georg C de Zubicaray, Greig I Thompson, Paul M Crone, Eveline A Frangou, Sophia Tamnes, Christian K Hum Brain Mapp Research Articles For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta‐Analysis) Consortium presents the largest‐ever mega‐analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1‐90 years old (47% females). We observed significant patterns of greater male than female between‐subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene‐environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex‐specific vulnerability to disorders. John Wiley & Sons, Inc. 2020-10-12 /pmc/articles/PMC8675415/ /pubmed/33044802 http://dx.doi.org/10.1002/hbm.25204 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Wierenga, Lara M Doucet, Gaelle E Dima, Danai Agartz, Ingrid Aghajani, Moji Akudjedu, Theophilus N Albajes‐Eizagirre, Anton Alnæs, Dag Alpert, Kathryn I Andreassen, Ole A Anticevic, Alan Asherson, Philip Banaschewski, Tobias Bargallo, Nuria Baumeister, Sarah Baur‐Streubel, Ramona Bertolino, Alessandro Bonvino, Aurora Boomsma, Dorret I Borgwardt, Stefan Bourque, Josiane den Braber, Anouk Brandeis, Daniel Breier, Alan Brodaty, Henry Brouwer, Rachel M Buitelaar, Jan K Busatto, Geraldo F Calhoun, Vince D Canales‐Rodríguez, Erick J Cannon, Dara M Caseras, Xavier Castellanos, Francisco X Chaim‐Avancini, Tiffany M Ching, Christopher RK Clark, Vincent P Conrod, Patricia J Conzelmann, Annette Crivello, Fabrice Davey, Christopher G Dickie, Erin W Ehrlich, Stefan van't Ent, Dennis Fisher, Simon E Fouche, Jean‐Paul Franke, Barbara Fuentes‐Claramonte, Paola de Geus, Eco JC Di Giorgio, Annabella Glahn, David C Gotlib, Ian H Grabe, Hans J Gruber, Oliver Gruner, Patricia Gur, Raquel E Gur, Ruben C Gurholt, Tiril P de Haan, Lieuwe Haatveit, Beathe Harrison, Ben J Hartman, Catharina A Hatton, Sean N Heslenfeld, Dirk J van den Heuvel, Odile A Hickie, Ian B Hoekstra, Pieter J Hohmann, Sarah Holmes, Avram J Hoogman, Martine Hosten, Norbert Howells, Fleur M Hulshoff Pol, Hilleke E Huyser, Chaim Jahanshad, Neda James, Anthony C Jiang, Jiyang Jönsson, Erik G Joska, John A Kalnin, Andrew J Klein, Marieke Koenders, Laura Kolskår, Knut K Krämer, Bernd Kuntsi, Jonna Lagopoulos, Jim Lazaro, Luisa Lebedeva, Irina S Lee, Phil H Lochner, Christine Machielsen, Marise WJ Maingault, Sophie Martin, Nicholas G Martínez‐Zalacaín, Ignacio Mataix‐Cols, David Mazoyer, Bernard McDonald, Brenna C McDonald, Colm McIntosh, Andrew M McMahon, Katie L McPhilemy, Genevieve van der Meer, Dennis Menchón, José M Naaijen, Jilly Nyberg, Lars Oosterlaan, Jaap Paloyelis, Yannis Pauli, Paul Pergola, Giulio Pomarol‐Clotet, Edith Portella, Maria J Radua, Joaquim Reif, Andreas Richard, Geneviève Roffman, Joshua L Rosa, Pedro GP Sacchet, Matthew D Sachdev, Perminder S Salvador, Raymond Sarró, Salvador Satterthwaite, Theodore D Saykin, Andrew J Serpa, Mauricio H Sim, Kang Simmons, Andrew Smoller, Jordan W Sommer, Iris E Soriano‐Mas, Carles Stein, Dan J Strike, Lachlan T Szeszko, Philip R Temmingh, Henk S Thomopoulos, Sophia I Tomyshev, Alexander S Trollor, Julian N Uhlmann, Anne Veer, Ilya M Veltman, Dick J Voineskos, Aristotle Völzke, Henry Walter, Henrik Wang, Lei Wang, Yang Weber, Bernd Wen, Wei West, John D Westlye, Lars T Whalley, Heather C Williams, Steven CR Wittfeld, Katharina Wolf, Daniel H Wright, Margaret J Yoncheva, Yuliya N Zanetti, Marcus V Ziegler, Georg C de Zubicaray, Greig I Thompson, Paul M Crone, Eveline A Frangou, Sophia Tamnes, Christian K Greater male than female variability in regional brain structure across the lifespan |
title | Greater male than female variability in regional brain structure across the lifespan |
title_full | Greater male than female variability in regional brain structure across the lifespan |
title_fullStr | Greater male than female variability in regional brain structure across the lifespan |
title_full_unstemmed | Greater male than female variability in regional brain structure across the lifespan |
title_short | Greater male than female variability in regional brain structure across the lifespan |
title_sort | greater male than female variability in regional brain structure across the lifespan |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675415/ https://www.ncbi.nlm.nih.gov/pubmed/33044802 http://dx.doi.org/10.1002/hbm.25204 |
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