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The impact of proline isomerization on antigen binding and the analytical profile of a trispecific anti-HIV antibody

Proline cis-trans conformational isomerization is a mechanism that affects different types of protein functions and behaviors. Using analytical characterization, structural analysis, and molecular dynamics simulations, we studied the causes of an aberrant two-peak size-exclusion chromatography profi...

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Detalles Bibliográficos
Autores principales:	Masiero, Alessandro, Nelly, Lechat, Marianne, Gentric, Christophe, Sourrouille, Florian, Laville, Ronan, Crépin, Claire, Borel, Cornelia, Ziegler, Grégoire, Bisch, Eric, Leclerc, Ludovic, Laurent, Dominique, Brault, Sylvie, Alexandre, Marie, Gagnaire, Francis, Duffieux, Fabienne, Soubrier, Cécile, Capdevila, Isabelle, Arnould, Jacques, Dumas, Jérôme, Dabin, Bruno, Genet, Katarina, Radošević, Jean-Michel, Menet, Catherine, Prades
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675452/ https://www.ncbi.nlm.nih.gov/pubmed/31791173 http://dx.doi.org/10.1080/19420862.2019.1698128

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