Cargando…

Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women

BACKGROUND: Previous studies have shown that the incidence and risk factors of gout differs according to sex. However, little research has been done on the association between reproductive factors and gout. We conducted an analysis of a large nationwide population-based cohort of postmenopausal wome...

Descripción completa

Detalles Bibliográficos
Autores principales: Eun, Yeonghee, Kim, In-Young, Han, Kyungdo, Lee, Kyu Na, Lee, Dong-Yun, Shin, Dong Wook, Kang, Seonyoung, Lee, Seulkee, Cha, Hoon-Suk, Koh, Eun-Mi, Lee, Jaejoon, Kim, Hyungjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675498/
https://www.ncbi.nlm.nih.gov/pubmed/34915918
http://dx.doi.org/10.1186/s13075-021-02701-w
_version_ 1784615882642685952
author Eun, Yeonghee
Kim, In-Young
Han, Kyungdo
Lee, Kyu Na
Lee, Dong-Yun
Shin, Dong Wook
Kang, Seonyoung
Lee, Seulkee
Cha, Hoon-Suk
Koh, Eun-Mi
Lee, Jaejoon
Kim, Hyungjin
author_facet Eun, Yeonghee
Kim, In-Young
Han, Kyungdo
Lee, Kyu Na
Lee, Dong-Yun
Shin, Dong Wook
Kang, Seonyoung
Lee, Seulkee
Cha, Hoon-Suk
Koh, Eun-Mi
Lee, Jaejoon
Kim, Hyungjin
author_sort Eun, Yeonghee
collection PubMed
description BACKGROUND: Previous studies have shown that the incidence and risk factors of gout differs according to sex. However, little research has been done on the association between reproductive factors and gout. We conducted an analysis of a large nationwide population-based cohort of postmenopausal women to determine whether there is an association between reproductive factors and the incidence of gout. METHODS: A total of 1,076,378 postmenopausal women aged 40–69 years who participated in national health screenings in 2009 were included in the study. The outcome was the occurrence of incident gout, which was defined using the ICD-10 code of gout (M10) in the claim database. Cox proportional hazard models were used for the analyses and stratified analyses according to body mass index (BMI) and the presence/absence of chronic kidney disease (CKD) were performed. RESULTS: The mean follow-up duration was 8.1 years, and incident cases of gout were 64,052 (incidence rate 7.31 per 1000 person-years). Later menarche, earlier menopause, and a shorter reproductive span were associated with a high risk of gout. No association between parity and gout incidence was observed. Use of oral contraceptives (OC) and hormone replacement therapy (HRT) were associated with an increased risk of gout. The association between reproductive factors and gout was not statistical significant in the high BMI group. The effects of OC and HRT usage on gout were not significant in the CKD group. CONCLUSION: Shorter exposure to endogenous estrogen was associated with a high risk of gout. Conversely, exposure to exogenous estrogen such as OC and HRT was associated with an increased risk of gout. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13075-021-02701-w.
format Online
Article
Text
id pubmed-8675498
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-86754982021-12-20 Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women Eun, Yeonghee Kim, In-Young Han, Kyungdo Lee, Kyu Na Lee, Dong-Yun Shin, Dong Wook Kang, Seonyoung Lee, Seulkee Cha, Hoon-Suk Koh, Eun-Mi Lee, Jaejoon Kim, Hyungjin Arthritis Res Ther Research Article BACKGROUND: Previous studies have shown that the incidence and risk factors of gout differs according to sex. However, little research has been done on the association between reproductive factors and gout. We conducted an analysis of a large nationwide population-based cohort of postmenopausal women to determine whether there is an association between reproductive factors and the incidence of gout. METHODS: A total of 1,076,378 postmenopausal women aged 40–69 years who participated in national health screenings in 2009 were included in the study. The outcome was the occurrence of incident gout, which was defined using the ICD-10 code of gout (M10) in the claim database. Cox proportional hazard models were used for the analyses and stratified analyses according to body mass index (BMI) and the presence/absence of chronic kidney disease (CKD) were performed. RESULTS: The mean follow-up duration was 8.1 years, and incident cases of gout were 64,052 (incidence rate 7.31 per 1000 person-years). Later menarche, earlier menopause, and a shorter reproductive span were associated with a high risk of gout. No association between parity and gout incidence was observed. Use of oral contraceptives (OC) and hormone replacement therapy (HRT) were associated with an increased risk of gout. The association between reproductive factors and gout was not statistical significant in the high BMI group. The effects of OC and HRT usage on gout were not significant in the CKD group. CONCLUSION: Shorter exposure to endogenous estrogen was associated with a high risk of gout. Conversely, exposure to exogenous estrogen such as OC and HRT was associated with an increased risk of gout. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13075-021-02701-w. BioMed Central 2021-12-16 2021 /pmc/articles/PMC8675498/ /pubmed/34915918 http://dx.doi.org/10.1186/s13075-021-02701-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Eun, Yeonghee
Kim, In-Young
Han, Kyungdo
Lee, Kyu Na
Lee, Dong-Yun
Shin, Dong Wook
Kang, Seonyoung
Lee, Seulkee
Cha, Hoon-Suk
Koh, Eun-Mi
Lee, Jaejoon
Kim, Hyungjin
Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women
title Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women
title_full Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women
title_fullStr Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women
title_full_unstemmed Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women
title_short Association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women
title_sort association between female reproductive factors and gout: a nationwide population-based cohort study of 1 million postmenopausal women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675498/
https://www.ncbi.nlm.nih.gov/pubmed/34915918
http://dx.doi.org/10.1186/s13075-021-02701-w
work_keys_str_mv AT eunyeonghee associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen
AT kiminyoung associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen
AT hankyungdo associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen
AT leekyuna associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen
AT leedongyun associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen
AT shindongwook associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen
AT kangseonyoung associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen
AT leeseulkee associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen
AT chahoonsuk associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen
AT koheunmi associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen
AT leejaejoon associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen
AT kimhyungjin associationbetweenfemalereproductivefactorsandgoutanationwidepopulationbasedcohortstudyof1millionpostmenopausalwomen