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Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple stu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675584/ https://www.ncbi.nlm.nih.gov/pubmed/34925244 http://dx.doi.org/10.3389/fendo.2021.785050 |
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author | Han, Changxi Lin, Shaojian Lu, Xingyu Xue, Li Wu, Zhe Bao |
author_facet | Han, Changxi Lin, Shaojian Lu, Xingyu Xue, Li Wu, Zhe Bao |
author_sort | Han, Changxi |
collection | PubMed |
description | Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple studies in other solid tumors, there is little known about macrophages in pituitary adenomas. Recently, studies about pituitary adenoma-infiltrated macrophages have been emerging, including the immunohistochemical and immunophenotypic analysis of the pituitary adenomas and further studies into the mechanism of the crosstalk between macrophages and tumor cells in vivo and in vitro. These studies have offered us new insights into the polarization of macrophages and its role in tumorigenesis, progression and invasion of pituitary adenomas. This review describes the advances in the field of pituitary adenoma-infiltrated macrophages and the prospect of targeting macrophages as cancer therapy in pituitary adenoma. |
format | Online Article Text |
id | pubmed-8675584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86755842021-12-17 Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches Han, Changxi Lin, Shaojian Lu, Xingyu Xue, Li Wu, Zhe Bao Front Endocrinol (Lausanne) Endocrinology Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple studies in other solid tumors, there is little known about macrophages in pituitary adenomas. Recently, studies about pituitary adenoma-infiltrated macrophages have been emerging, including the immunohistochemical and immunophenotypic analysis of the pituitary adenomas and further studies into the mechanism of the crosstalk between macrophages and tumor cells in vivo and in vitro. These studies have offered us new insights into the polarization of macrophages and its role in tumorigenesis, progression and invasion of pituitary adenomas. This review describes the advances in the field of pituitary adenoma-infiltrated macrophages and the prospect of targeting macrophages as cancer therapy in pituitary adenoma. Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8675584/ /pubmed/34925244 http://dx.doi.org/10.3389/fendo.2021.785050 Text en Copyright © 2021 Han, Lin, Lu, Xue and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Han, Changxi Lin, Shaojian Lu, Xingyu Xue, Li Wu, Zhe Bao Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches |
title | Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches |
title_full | Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches |
title_fullStr | Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches |
title_full_unstemmed | Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches |
title_short | Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches |
title_sort | tumor-associated macrophages: new horizons for pituitary adenoma researches |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675584/ https://www.ncbi.nlm.nih.gov/pubmed/34925244 http://dx.doi.org/10.3389/fendo.2021.785050 |
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