Cargando…

Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches

Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple stu...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Changxi, Lin, Shaojian, Lu, Xingyu, Xue, Li, Wu, Zhe Bao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675584/
https://www.ncbi.nlm.nih.gov/pubmed/34925244
http://dx.doi.org/10.3389/fendo.2021.785050
_version_ 1784615899347550208
author Han, Changxi
Lin, Shaojian
Lu, Xingyu
Xue, Li
Wu, Zhe Bao
author_facet Han, Changxi
Lin, Shaojian
Lu, Xingyu
Xue, Li
Wu, Zhe Bao
author_sort Han, Changxi
collection PubMed
description Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple studies in other solid tumors, there is little known about macrophages in pituitary adenomas. Recently, studies about pituitary adenoma-infiltrated macrophages have been emerging, including the immunohistochemical and immunophenotypic analysis of the pituitary adenomas and further studies into the mechanism of the crosstalk between macrophages and tumor cells in vivo and in vitro. These studies have offered us new insights into the polarization of macrophages and its role in tumorigenesis, progression and invasion of pituitary adenomas. This review describes the advances in the field of pituitary adenoma-infiltrated macrophages and the prospect of targeting macrophages as cancer therapy in pituitary adenoma.
format Online
Article
Text
id pubmed-8675584
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86755842021-12-17 Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches Han, Changxi Lin, Shaojian Lu, Xingyu Xue, Li Wu, Zhe Bao Front Endocrinol (Lausanne) Endocrinology Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple studies in other solid tumors, there is little known about macrophages in pituitary adenomas. Recently, studies about pituitary adenoma-infiltrated macrophages have been emerging, including the immunohistochemical and immunophenotypic analysis of the pituitary adenomas and further studies into the mechanism of the crosstalk between macrophages and tumor cells in vivo and in vitro. These studies have offered us new insights into the polarization of macrophages and its role in tumorigenesis, progression and invasion of pituitary adenomas. This review describes the advances in the field of pituitary adenoma-infiltrated macrophages and the prospect of targeting macrophages as cancer therapy in pituitary adenoma. Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8675584/ /pubmed/34925244 http://dx.doi.org/10.3389/fendo.2021.785050 Text en Copyright © 2021 Han, Lin, Lu, Xue and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Han, Changxi
Lin, Shaojian
Lu, Xingyu
Xue, Li
Wu, Zhe Bao
Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
title Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
title_full Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
title_fullStr Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
title_full_unstemmed Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
title_short Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
title_sort tumor-associated macrophages: new horizons for pituitary adenoma researches
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675584/
https://www.ncbi.nlm.nih.gov/pubmed/34925244
http://dx.doi.org/10.3389/fendo.2021.785050
work_keys_str_mv AT hanchangxi tumorassociatedmacrophagesnewhorizonsforpituitaryadenomaresearches
AT linshaojian tumorassociatedmacrophagesnewhorizonsforpituitaryadenomaresearches
AT luxingyu tumorassociatedmacrophagesnewhorizonsforpituitaryadenomaresearches
AT xueli tumorassociatedmacrophagesnewhorizonsforpituitaryadenomaresearches
AT wuzhebao tumorassociatedmacrophagesnewhorizonsforpituitaryadenomaresearches