Leptomeningeal Disease as an Initial Presenting Manifestation in Breast Cancer

Leptomeningeal disease (LMD) occurs in less than 5% of breast cancer patients. Rarely, patients present with LMD at diagnosis. We report a case of a 59-year-old female who presented with lower back pain, radicular neuropathy with lower extremity weakness, and was found to have diffuse LMD. Workup wa...

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Detalles Bibliográficos
Autores principales: Shrestha, Jasmine, Shrestha, Asis, Karki, Pratul, Dhakal, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675594/
https://www.ncbi.nlm.nih.gov/pubmed/34956772
http://dx.doi.org/10.7759/cureus.19666
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author Shrestha, Jasmine
Shrestha, Asis
Karki, Pratul
Dhakal, Ajay
author_facet Shrestha, Jasmine
Shrestha, Asis
Karki, Pratul
Dhakal, Ajay
author_sort Shrestha, Jasmine
collection PubMed
description Leptomeningeal disease (LMD) occurs in less than 5% of breast cancer patients. Rarely, patients present with LMD at diagnosis. We report a case of a 59-year-old female who presented with lower back pain, radicular neuropathy with lower extremity weakness, and was found to have diffuse LMD. Workup was initiated to evaluate the etiology of LMD and later involved iliac bone biopsy showed metastatic adenocarcinoma consistent with breast carcinoma. Patient received radiation therapy followed by abemaciclib with letrozole and responded well with the treatment.
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spelling pubmed-86755942021-12-23 Leptomeningeal Disease as an Initial Presenting Manifestation in Breast Cancer Shrestha, Jasmine Shrestha, Asis Karki, Pratul Dhakal, Ajay Cureus Neurology Leptomeningeal disease (LMD) occurs in less than 5% of breast cancer patients. Rarely, patients present with LMD at diagnosis. We report a case of a 59-year-old female who presented with lower back pain, radicular neuropathy with lower extremity weakness, and was found to have diffuse LMD. Workup was initiated to evaluate the etiology of LMD and later involved iliac bone biopsy showed metastatic adenocarcinoma consistent with breast carcinoma. Patient received radiation therapy followed by abemaciclib with letrozole and responded well with the treatment. Cureus 2021-11-17 /pmc/articles/PMC8675594/ /pubmed/34956772 http://dx.doi.org/10.7759/cureus.19666 Text en Copyright © 2021, Shrestha et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Shrestha, Jasmine
Shrestha, Asis
Karki, Pratul
Dhakal, Ajay
Leptomeningeal Disease as an Initial Presenting Manifestation in Breast Cancer
title Leptomeningeal Disease as an Initial Presenting Manifestation in Breast Cancer
title_full Leptomeningeal Disease as an Initial Presenting Manifestation in Breast Cancer
title_fullStr Leptomeningeal Disease as an Initial Presenting Manifestation in Breast Cancer
title_full_unstemmed Leptomeningeal Disease as an Initial Presenting Manifestation in Breast Cancer
title_short Leptomeningeal Disease as an Initial Presenting Manifestation in Breast Cancer
title_sort leptomeningeal disease as an initial presenting manifestation in breast cancer
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675594/
https://www.ncbi.nlm.nih.gov/pubmed/34956772
http://dx.doi.org/10.7759/cureus.19666
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AT karkipratul leptomeningealdiseaseasaninitialpresentingmanifestationinbreastcancer
AT dhakalajay leptomeningealdiseaseasaninitialpresentingmanifestationinbreastcancer

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