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Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce neurotoxicity in vitro and in vivo. The small GTPase Rab8a is a LRRK2 kin...
Autores principales: | Mamais, Adamantios, Kluss, Jillian H., Bonet-Ponce, Luis, Landeck, Natalie, Langston, Rebekah G., Smith, Nathan, Beilina, Alexandra, Kaganovich, Alice, Ghosh, Manik C., Pellegrini, Laura, Kumaran, Ravindran, Papazoglou, Ioannis, Heaton, George R., Bandopadhyay, Rina, Maio, Nunziata, Kim, Changyoun, LaVoie, Matthew J., Gershlick, David C., Cookson, Mark R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675653/ https://www.ncbi.nlm.nih.gov/pubmed/34914695 http://dx.doi.org/10.1371/journal.pbio.3001480 |
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