Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status

Cell competition induces the elimination of less-fit “loser” cells by fitter “winner” cells. In Drosophila, cells heterozygous mutant in ribosome genes, Rp/+, known as Minutes, are outcompeted by wild-type cells. Rp/+ cells display proteotoxic stress and the oxidative stress response, which drive th...

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Detalles Bibliográficos
Autores principales: Langton, Paul F., Baumgartner, Michael E., Logeay, Remi, Piddini, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675655/
https://www.ncbi.nlm.nih.gov/pubmed/34914692
http://dx.doi.org/10.1371/journal.pgen.1009946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675655/
https://www.ncbi.nlm.nih.gov/pubmed/34914692
http://dx.doi.org/10.1371/journal.pgen.1009946

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