Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats

Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC‐loaded PLA Nanoparticles (TC‐PLA NPs) on streptozotocin (STZ)‐induced diabetic nephropathy rats was investigate...

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Detalles Bibliográficos
Autores principales: Ambalavanan, Ragavee, John, Arul Daniel, Selvaraj, Asha Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675778/
https://www.ncbi.nlm.nih.gov/pubmed/34694717
http://dx.doi.org/10.1049/nbt2.12030
Descripción
Sumario:Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC‐loaded PLA Nanoparticles (TC‐PLA NPs) on streptozotocin (STZ)‐induced diabetic nephropathy rats was investigated. The results showed that the nephroprotective effect of TC‐PLA NPs reduces the blood glucose level, regulates the renal parameters, decreases the cytokine levels and reduces the mRNA expressions level of different genes related to diabetic nephropathy.

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