Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats

Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC‐loaded PLA Nanoparticles (TC‐PLA NPs) on streptozotocin (STZ)‐induced diabetic nephropathy rats was investigate...

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Detalles Bibliográficos
Autores principales: Ambalavanan, Ragavee, John, Arul Daniel, Selvaraj, Asha Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675778/
https://www.ncbi.nlm.nih.gov/pubmed/34694717
http://dx.doi.org/10.1049/nbt2.12030
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author Ambalavanan, Ragavee
John, Arul Daniel
Selvaraj, Asha Devi
author_facet Ambalavanan, Ragavee
John, Arul Daniel
Selvaraj, Asha Devi
author_sort Ambalavanan, Ragavee
collection PubMed
description Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC‐loaded PLA Nanoparticles (TC‐PLA NPs) on streptozotocin (STZ)‐induced diabetic nephropathy rats was investigated. The results showed that the nephroprotective effect of TC‐PLA NPs reduces the blood glucose level, regulates the renal parameters, decreases the cytokine levels and reduces the mRNA expressions level of different genes related to diabetic nephropathy.
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spelling pubmed-86757782022-02-03 Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats Ambalavanan, Ragavee John, Arul Daniel Selvaraj, Asha Devi IET Nanobiotechnol Original Research Paper Currently, the field of nanomedicine, which uses active compounds from medicinal plants, has emerged as a therapy for diabetic nephropathy. From this study, the renoprotective effect of TC‐loaded PLA Nanoparticles (TC‐PLA NPs) on streptozotocin (STZ)‐induced diabetic nephropathy rats was investigated. The results showed that the nephroprotective effect of TC‐PLA NPs reduces the blood glucose level, regulates the renal parameters, decreases the cytokine levels and reduces the mRNA expressions level of different genes related to diabetic nephropathy. John Wiley and Sons Inc. 2021-03-15 /pmc/articles/PMC8675778/ /pubmed/34694717 http://dx.doi.org/10.1049/nbt2.12030 Text en © 2021 The Authors. IET Nanobiotechnology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research Paper
Ambalavanan, Ragavee
John, Arul Daniel
Selvaraj, Asha Devi
Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats
title Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats
title_full Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats
title_fullStr Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats
title_full_unstemmed Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats
title_short Nephroprotective role of nanoencapsulated Tinospora cordifolia (Willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats
title_sort nephroprotective role of nanoencapsulated tinospora cordifolia (willd.) using polylactic acid nanoparticles in streptozotocin‐induced diabetic nephropathy rats
topic Original Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675778/
https://www.ncbi.nlm.nih.gov/pubmed/34694717
http://dx.doi.org/10.1049/nbt2.12030
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