One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment

The drug nanoparticles free of additional carriers hold great promise in drug delivery and are suitable for the therapy of cancers. Herein, we developed a one‐pot method to prepare chlorin e6 (Ce6) nano‐precipitations (Ce6 NPs) for effective photodynamic therapy of colorectal cancer. The drug loadin...

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Detalles Bibliográficos
Autores principales: Miao, Zhongxing, Wang, Yujie, Li, Shengjie, Zhang, Min, Xu, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675780/
https://www.ncbi.nlm.nih.gov/pubmed/34694720
http://dx.doi.org/10.1049/nbt2.12065
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author Miao, Zhongxing
Wang, Yujie
Li, Shengjie
Zhang, Min
Xu, Meng
author_facet Miao, Zhongxing
Wang, Yujie
Li, Shengjie
Zhang, Min
Xu, Meng
author_sort Miao, Zhongxing
collection PubMed
description The drug nanoparticles free of additional carriers hold great promise in drug delivery and are suitable for the therapy of cancers. Herein, we developed a one‐pot method to prepare chlorin e6 (Ce6) nano‐precipitations (Ce6 NPs) for effective photodynamic therapy of colorectal cancer. The drug loading of Ce6 NPs was around 81% and showed acceptable stability, high biocompatibility as well as effective reactive oxygen species (ROS) generation capability. As a result, the Ce6 NPs can produce significantly elevated ROS upon laser irradiations and achieved better anticancer benefits than free Ce6.
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spelling pubmed-86757802022-02-03 One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment Miao, Zhongxing Wang, Yujie Li, Shengjie Zhang, Min Xu, Meng IET Nanobiotechnol Original Research Papers The drug nanoparticles free of additional carriers hold great promise in drug delivery and are suitable for the therapy of cancers. Herein, we developed a one‐pot method to prepare chlorin e6 (Ce6) nano‐precipitations (Ce6 NPs) for effective photodynamic therapy of colorectal cancer. The drug loading of Ce6 NPs was around 81% and showed acceptable stability, high biocompatibility as well as effective reactive oxygen species (ROS) generation capability. As a result, the Ce6 NPs can produce significantly elevated ROS upon laser irradiations and achieved better anticancer benefits than free Ce6. John Wiley and Sons Inc. 2021-07-21 /pmc/articles/PMC8675780/ /pubmed/34694720 http://dx.doi.org/10.1049/nbt2.12065 Text en © 2021 The Authors. IET Nanobiotechnology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research Papers
Miao, Zhongxing
Wang, Yujie
Li, Shengjie
Zhang, Min
Xu, Meng
One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment
title One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment
title_full One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment
title_fullStr One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment
title_full_unstemmed One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment
title_short One‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment Ce6 NPs for colorectal cancer treatment
title_sort one‐pot synthesis chlorin e6 nano‐precipitation for colorectal cancer treatment ce6 nps for colorectal cancer treatment
topic Original Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675780/
https://www.ncbi.nlm.nih.gov/pubmed/34694720
http://dx.doi.org/10.1049/nbt2.12065
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