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Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles
Silicon dioxide nanoparticles (SiO(2) NPs) are widely invested in medicine, industry, agriculture, consuming products, optical imaging agents, cosmetics, and drug delivery. However, the toxicity of these NPs on human health and the ecosystem have not been extensively studied and little information i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675786/ https://www.ncbi.nlm.nih.gov/pubmed/34694701 http://dx.doi.org/10.1049/nbt2.12041 |
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author | Jarrar, Bashir Al‐Doaiss, Amin Shati, Ali Al‐Kahtani, Mohammed Jarrar, Qais |
author_facet | Jarrar, Bashir Al‐Doaiss, Amin Shati, Ali Al‐Kahtani, Mohammed Jarrar, Qais |
author_sort | Jarrar, Bashir |
collection | PubMed |
description | Silicon dioxide nanoparticles (SiO(2) NPs) are widely invested in medicine, industry, agriculture, consuming products, optical imaging agents, cosmetics, and drug delivery. However, the toxicity of these NPs on human health and the ecosystem have not been extensively studied and little information is available about their behavioural toxicities. The current study aimed to find out the behavioural alterations that might be induced by chronic exposure to 10 nm SiO(2) NPs. BALB/C mice were subjected to 36 injections of SiO(2) NPs (2 mg/kg Bw) and subjected to 11 neurobehavioural tests: elevated plus‐maze test, elevated zero‐maze test, multiradial maze test, open field test, hole‐board test, light‐dark box test, forced swimming test, tail‐suspension test, Morris water‐maze test, Y‐maze test and multiple T‐maze test. Treated mice demonstrated anxiety‐like effect, depression tendency, behavioural despair stress, exploration and locomotors activity reduction with error induction in both reference and working memories. The findings may suggest that silica NPs are anxiogenic and could aggravate depression affecting memory, learning, overall activity and exploratory behaviour. Moreover, the findings may indicate that these nanomaterials (NMs) may induce potential oxidative stress in the body leading to neurobehavioural alterations with possible changes in the vital organ including the central nervous system. |
format | Online Article Text |
id | pubmed-8675786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86757862022-02-03 Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles Jarrar, Bashir Al‐Doaiss, Amin Shati, Ali Al‐Kahtani, Mohammed Jarrar, Qais IET Nanobiotechnol Original Research Papers Silicon dioxide nanoparticles (SiO(2) NPs) are widely invested in medicine, industry, agriculture, consuming products, optical imaging agents, cosmetics, and drug delivery. However, the toxicity of these NPs on human health and the ecosystem have not been extensively studied and little information is available about their behavioural toxicities. The current study aimed to find out the behavioural alterations that might be induced by chronic exposure to 10 nm SiO(2) NPs. BALB/C mice were subjected to 36 injections of SiO(2) NPs (2 mg/kg Bw) and subjected to 11 neurobehavioural tests: elevated plus‐maze test, elevated zero‐maze test, multiradial maze test, open field test, hole‐board test, light‐dark box test, forced swimming test, tail‐suspension test, Morris water‐maze test, Y‐maze test and multiple T‐maze test. Treated mice demonstrated anxiety‐like effect, depression tendency, behavioural despair stress, exploration and locomotors activity reduction with error induction in both reference and working memories. The findings may suggest that silica NPs are anxiogenic and could aggravate depression affecting memory, learning, overall activity and exploratory behaviour. Moreover, the findings may indicate that these nanomaterials (NMs) may induce potential oxidative stress in the body leading to neurobehavioural alterations with possible changes in the vital organ including the central nervous system. John Wiley and Sons Inc. 2021-03-23 /pmc/articles/PMC8675786/ /pubmed/34694701 http://dx.doi.org/10.1049/nbt2.12041 Text en © 2021 The Authors. IET Nanobiotechnology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Papers Jarrar, Bashir Al‐Doaiss, Amin Shati, Ali Al‐Kahtani, Mohammed Jarrar, Qais Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
title | Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
title_full | Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
title_fullStr | Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
title_full_unstemmed | Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
title_short | Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
title_sort | behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles |
topic | Original Research Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675786/ https://www.ncbi.nlm.nih.gov/pubmed/34694701 http://dx.doi.org/10.1049/nbt2.12041 |
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