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Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems
This article reports on the mechanical strength analysis and flow characteristics of square tip and circular tip microneedles by employing highly potent drugs that are given in extremely little quantity (microlitres) using MEMS technology, which proves to be a significant component of micropump in t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675835/ https://www.ncbi.nlm.nih.gov/pubmed/34694756 http://dx.doi.org/10.1049/nbt2.12013 |
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author | Karumuri, Srinivasa R. Mohammed, Hamza Guha, Koushik Puli, Ashok K. Einsanwi, Ameen Kondavitee, Girija S. |
author_facet | Karumuri, Srinivasa R. Mohammed, Hamza Guha, Koushik Puli, Ashok K. Einsanwi, Ameen Kondavitee, Girija S. |
author_sort | Karumuri, Srinivasa R. |
collection | PubMed |
description | This article reports on the mechanical strength analysis and flow characteristics of square tip and circular tip microneedles by employing highly potent drugs that are given in extremely little quantity (microlitres) using MEMS technology, which proves to be a significant component of micropump in the application of Bio‐MEMS. These microneedles are well suitable for a MEMS‐based micropump in the drug delivery systems. It is an essential part of the micropump through which the drug is released into the patient’s body. The proposed microneedles can withstand a stress of 23 MPa and 20 KPa. An extensive investigation on selection of material for the microneedle is carried out to meet the requirements of the biocompatibility and high yield, as well as tensile strength. As mighty drugs such as vasopressin, atropine and digoxin are administered in large quantities, the microneedle is designed so as to deliver 800 µl of drug, with each microneedle delivering 90 µl. in a 3 3 array. 3 × 3 array releasing 90 µl. |
format | Online Article Text |
id | pubmed-8675835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86758352022-02-03 Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems Karumuri, Srinivasa R. Mohammed, Hamza Guha, Koushik Puli, Ashok K. Einsanwi, Ameen Kondavitee, Girija S. IET Nanobiotechnol Original Research Papers This article reports on the mechanical strength analysis and flow characteristics of square tip and circular tip microneedles by employing highly potent drugs that are given in extremely little quantity (microlitres) using MEMS technology, which proves to be a significant component of micropump in the application of Bio‐MEMS. These microneedles are well suitable for a MEMS‐based micropump in the drug delivery systems. It is an essential part of the micropump through which the drug is released into the patient’s body. The proposed microneedles can withstand a stress of 23 MPa and 20 KPa. An extensive investigation on selection of material for the microneedle is carried out to meet the requirements of the biocompatibility and high yield, as well as tensile strength. As mighty drugs such as vasopressin, atropine and digoxin are administered in large quantities, the microneedle is designed so as to deliver 800 µl of drug, with each microneedle delivering 90 µl. in a 3 3 array. 3 × 3 array releasing 90 µl. John Wiley and Sons Inc. 2021-03-30 /pmc/articles/PMC8675835/ /pubmed/34694756 http://dx.doi.org/10.1049/nbt2.12013 Text en © 2021 The Authors. IET Nanobiotechnology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Papers Karumuri, Srinivasa R. Mohammed, Hamza Guha, Koushik Puli, Ashok K. Einsanwi, Ameen Kondavitee, Girija S. Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
title | Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
title_full | Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
title_fullStr | Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
title_full_unstemmed | Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
title_short | Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
title_sort | design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems |
topic | Original Research Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675835/ https://www.ncbi.nlm.nih.gov/pubmed/34694756 http://dx.doi.org/10.1049/nbt2.12013 |
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