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Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems

This article reports on the mechanical strength analysis and flow characteristics of square tip and circular tip microneedles by employing highly potent drugs that are given in extremely little quantity (microlitres) using MEMS technology, which proves to be a significant component of micropump in t...

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Autores principales: Karumuri, Srinivasa R., Mohammed, Hamza, Guha, Koushik, Puli, Ashok K., Einsanwi, Ameen, Kondavitee, Girija S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675835/
https://www.ncbi.nlm.nih.gov/pubmed/34694756
http://dx.doi.org/10.1049/nbt2.12013
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author Karumuri, Srinivasa R.
Mohammed, Hamza
Guha, Koushik
Puli, Ashok K.
Einsanwi, Ameen
Kondavitee, Girija S.
author_facet Karumuri, Srinivasa R.
Mohammed, Hamza
Guha, Koushik
Puli, Ashok K.
Einsanwi, Ameen
Kondavitee, Girija S.
author_sort Karumuri, Srinivasa R.
collection PubMed
description This article reports on the mechanical strength analysis and flow characteristics of square tip and circular tip microneedles by employing highly potent drugs that are given in extremely little quantity (microlitres) using MEMS technology, which proves to be a significant component of micropump in the application of Bio‐MEMS. These microneedles are well suitable for a MEMS‐based micropump in the drug delivery systems. It is an essential part of the micropump through which the drug is released into the patient’s body. The proposed microneedles can withstand a stress of 23 MPa and 20 KPa. An extensive investigation on selection of material for the microneedle is carried out to meet the requirements of the biocompatibility and high yield, as well as tensile strength. As mighty drugs such as vasopressin, atropine and digoxin are administered in large quantities, the microneedle is designed so as to deliver 800 µl of drug, with each microneedle delivering 90 µl. in a 3 3 array. 3 × 3 array releasing 90 µl.
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spelling pubmed-86758352022-02-03 Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems Karumuri, Srinivasa R. Mohammed, Hamza Guha, Koushik Puli, Ashok K. Einsanwi, Ameen Kondavitee, Girija S. IET Nanobiotechnol Original Research Papers This article reports on the mechanical strength analysis and flow characteristics of square tip and circular tip microneedles by employing highly potent drugs that are given in extremely little quantity (microlitres) using MEMS technology, which proves to be a significant component of micropump in the application of Bio‐MEMS. These microneedles are well suitable for a MEMS‐based micropump in the drug delivery systems. It is an essential part of the micropump through which the drug is released into the patient’s body. The proposed microneedles can withstand a stress of 23 MPa and 20 KPa. An extensive investigation on selection of material for the microneedle is carried out to meet the requirements of the biocompatibility and high yield, as well as tensile strength. As mighty drugs such as vasopressin, atropine and digoxin are administered in large quantities, the microneedle is designed so as to deliver 800 µl of drug, with each microneedle delivering 90 µl. in a 3 3 array. 3 × 3 array releasing 90 µl. John Wiley and Sons Inc. 2021-03-30 /pmc/articles/PMC8675835/ /pubmed/34694756 http://dx.doi.org/10.1049/nbt2.12013 Text en © 2021 The Authors. IET Nanobiotechnology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Papers
Karumuri, Srinivasa R.
Mohammed, Hamza
Guha, Koushik
Puli, Ashok K.
Einsanwi, Ameen
Kondavitee, Girija S.
Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems
title Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems
title_full Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems
title_fullStr Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems
title_full_unstemmed Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems
title_short Design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems
title_sort design, simulation and analysis of micro electro‐mechanical system microneedle for micropump in drug delivery systems
topic Original Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675835/
https://www.ncbi.nlm.nih.gov/pubmed/34694756
http://dx.doi.org/10.1049/nbt2.12013
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