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Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System
Endocannabinoid (eCB) signaling plays an important role in the central nervous system (CNS). α/β-Hydrolase domain-containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes monoacylglycerol (MAG) lipids such as endocannabinoid 2-arachidonoyl glycerol (2-AG). ABHD6 participates in neuro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675881/ https://www.ncbi.nlm.nih.gov/pubmed/34925039 http://dx.doi.org/10.3389/fphar.2021.784202 |
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author | Zhang, Haofuzi Li, Xin Liao, Dan Luo, Peng Jiang, Xiaofan |
author_facet | Zhang, Haofuzi Li, Xin Liao, Dan Luo, Peng Jiang, Xiaofan |
author_sort | Zhang, Haofuzi |
collection | PubMed |
description | Endocannabinoid (eCB) signaling plays an important role in the central nervous system (CNS). α/β-Hydrolase domain-containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes monoacylglycerol (MAG) lipids such as endocannabinoid 2-arachidonoyl glycerol (2-AG). ABHD6 participates in neurotransmission, inflammation, brain energy metabolism, tumorigenesis and other biological processes and is a potential therapeutic target for various neurological diseases, such as traumatic brain injury (TBI), multiple sclerosis (MS), epilepsy, mental illness, and pain. This review summarizes the molecular mechanisms of action and biological functions of ABHD6, particularly its mechanism of action in the pathogenesis of neurological diseases, and provides a theoretical basis for new pharmacological interventions via targeting of ABHD6. |
format | Online Article Text |
id | pubmed-8675881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86758812021-12-17 Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System Zhang, Haofuzi Li, Xin Liao, Dan Luo, Peng Jiang, Xiaofan Front Pharmacol Pharmacology Endocannabinoid (eCB) signaling plays an important role in the central nervous system (CNS). α/β-Hydrolase domain-containing 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes monoacylglycerol (MAG) lipids such as endocannabinoid 2-arachidonoyl glycerol (2-AG). ABHD6 participates in neurotransmission, inflammation, brain energy metabolism, tumorigenesis and other biological processes and is a potential therapeutic target for various neurological diseases, such as traumatic brain injury (TBI), multiple sclerosis (MS), epilepsy, mental illness, and pain. This review summarizes the molecular mechanisms of action and biological functions of ABHD6, particularly its mechanism of action in the pathogenesis of neurological diseases, and provides a theoretical basis for new pharmacological interventions via targeting of ABHD6. Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8675881/ /pubmed/34925039 http://dx.doi.org/10.3389/fphar.2021.784202 Text en Copyright © 2021 Zhang, Li, Liao, Luo and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Zhang, Haofuzi Li, Xin Liao, Dan Luo, Peng Jiang, Xiaofan Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System |
title | Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System |
title_full | Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System |
title_fullStr | Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System |
title_full_unstemmed | Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System |
title_short | Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System |
title_sort | alpha/beta-hydrolase domain-containing 6: signaling and function in the central nervous system |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675881/ https://www.ncbi.nlm.nih.gov/pubmed/34925039 http://dx.doi.org/10.3389/fphar.2021.784202 |
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