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β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy

G protein–coupled receptors (GPCRs) have been shown to play integral roles in Alzheimer’s disease pathogenesis. However, it is unclear how diverse GPCRs similarly affect Aβ and tau pathogenesis. GPCRs share a common mechanism of action via the β-arrestin scaffolding signaling complexes, which not on...

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Detalles Bibliográficos
Autores principales:	Woo, Jung-AA, Yan, Yan, Kee, Teresa R, Cazzaro, Sara, McGill Percy, Kyle C, Wang, Xinming, Liu, Tian, Liggett, Stephen B, Kang, David E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675912/ https://www.ncbi.nlm.nih.gov/pubmed/34862271 http://dx.doi.org/10.26508/lsa.202101183

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