Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication

Emerging coronaviruses (CoVs) pose a severe threat to human and animal health worldwide. To identify host factors required for CoV infection, we used α-CoV transmissible gastroenteritis virus (TGEV) as a model for genome-scale CRISPR knockout (KO) screening. Transmembrane protein 41B (TMEM41B) was f...

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Detalles Bibliográficos
Autores principales: Sun, Limeng, Zhao, Changzhi, Fu, Zhen, Fu, Yanan, Su, Zhelin, Li, Yangyang, Zhou, Yuan, Tan, Yubei, Li, Jingjin, Xiang, Yixin, Nie, Xiongwei, Zhang, Jinfu, Liu, Fei, Zhao, Shuhong, Xie, Shengsong, Peng, Guiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675922/
https://www.ncbi.nlm.nih.gov/pubmed/34871328
http://dx.doi.org/10.1371/journal.ppat.1010113

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