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Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1

Variations in the availability of nutritional resources in animals can trigger reversible adjustments, which in the short term are manifested as behavioral and physiological changes. Several of these responses are mediated by Sirt1, which acts as an energy status sensor governing a global genetic pr...

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Autores principales: Peña-Villalobos, Isaac, Otárola, Fabiola A., Casas, Bárbara S., Sabat, Pablo, Palma, Verónica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675943/
https://www.ncbi.nlm.nih.gov/pubmed/34925065
http://dx.doi.org/10.3389/fphys.2021.769444
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author Peña-Villalobos, Isaac
Otárola, Fabiola A.
Casas, Bárbara S.
Sabat, Pablo
Palma, Verónica
author_facet Peña-Villalobos, Isaac
Otárola, Fabiola A.
Casas, Bárbara S.
Sabat, Pablo
Palma, Verónica
author_sort Peña-Villalobos, Isaac
collection PubMed
description Variations in the availability of nutritional resources in animals can trigger reversible adjustments, which in the short term are manifested as behavioral and physiological changes. Several of these responses are mediated by Sirt1, which acts as an energy status sensor governing a global genetic program to cope with changes in nutritional status. Growing evidence suggests a key role of the response of the perinatal environment to caloric restriction in the setup of physiological responses in adulthood. The existence of adaptive predictive responses has been proposed, which suggests that early nutrition could establish metabolic capacities suitable for future food-scarce environments. We evaluated how perinatal food deprivation and maternal gestational weight gain impact the transcriptional, physiological, and behavioral responses in mice, when acclimated to caloric restriction in adulthood. Our results show a strong predictive capacity of maternal weight and gestational weight gain, in the expression of Sirt1 and its downstream targets in the brain and liver, mitochondrial enzymatic activity in skeletal muscle, and exploratory behavior in offspring. We also observed differential responses of both lactation and gestational food restriction on gene expression, thermogenesis, organ masses, and behavior, in response to adult caloric restriction. We conclude that the early nutritional state could determine the magnitude of responses to food scarcity later in adulthood, mediated by the pivotal metabolic sensor Sirt1. Our results suggest that maternal gestational weight gain could be an important life history trait and could be used to predict features that improve the invasive capacity or adjustment to seasonal food scarcity of the offspring.
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spelling pubmed-86759432021-12-17 Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1 Peña-Villalobos, Isaac Otárola, Fabiola A. Casas, Bárbara S. Sabat, Pablo Palma, Verónica Front Physiol Physiology Variations in the availability of nutritional resources in animals can trigger reversible adjustments, which in the short term are manifested as behavioral and physiological changes. Several of these responses are mediated by Sirt1, which acts as an energy status sensor governing a global genetic program to cope with changes in nutritional status. Growing evidence suggests a key role of the response of the perinatal environment to caloric restriction in the setup of physiological responses in adulthood. The existence of adaptive predictive responses has been proposed, which suggests that early nutrition could establish metabolic capacities suitable for future food-scarce environments. We evaluated how perinatal food deprivation and maternal gestational weight gain impact the transcriptional, physiological, and behavioral responses in mice, when acclimated to caloric restriction in adulthood. Our results show a strong predictive capacity of maternal weight and gestational weight gain, in the expression of Sirt1 and its downstream targets in the brain and liver, mitochondrial enzymatic activity in skeletal muscle, and exploratory behavior in offspring. We also observed differential responses of both lactation and gestational food restriction on gene expression, thermogenesis, organ masses, and behavior, in response to adult caloric restriction. We conclude that the early nutritional state could determine the magnitude of responses to food scarcity later in adulthood, mediated by the pivotal metabolic sensor Sirt1. Our results suggest that maternal gestational weight gain could be an important life history trait and could be used to predict features that improve the invasive capacity or adjustment to seasonal food scarcity of the offspring. Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8675943/ /pubmed/34925065 http://dx.doi.org/10.3389/fphys.2021.769444 Text en Copyright © 2021 Peña-Villalobos, Otárola, Casas, Sabat and Palma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Peña-Villalobos, Isaac
Otárola, Fabiola A.
Casas, Bárbara S.
Sabat, Pablo
Palma, Verónica
Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
title Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
title_full Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
title_fullStr Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
title_full_unstemmed Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
title_short Perinatal Food Deprivation Modifies the Caloric Restriction Response in Adult Mice Through Sirt1
title_sort perinatal food deprivation modifies the caloric restriction response in adult mice through sirt1
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675943/
https://www.ncbi.nlm.nih.gov/pubmed/34925065
http://dx.doi.org/10.3389/fphys.2021.769444
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