Variations in transfer and ribosomal RNA epitranscriptomic status can adapt eukaryote translation to changing physiological and environmental conditions

The timely reprogramming of gene expression in response to internal and external cues is essential to eukaryote development and acclimation to changing environments. Chemically modifying molecular receptors and transducers of these signals is one way to efficiently induce proper physiological respon...

Descripción completa

Detalles Bibliográficos
Autores principales: Dannfald, Arnaud, Favory, Jean-Jacques, Deragon, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677040/
https://www.ncbi.nlm.nih.gov/pubmed/34159889
http://dx.doi.org/10.1080/15476286.2021.1931756
_version_ 1784616058409189376
author Dannfald, Arnaud
Favory, Jean-Jacques
Deragon, Jean-Marc
author_facet Dannfald, Arnaud
Favory, Jean-Jacques
Deragon, Jean-Marc
author_sort Dannfald, Arnaud
collection PubMed
description The timely reprogramming of gene expression in response to internal and external cues is essential to eukaryote development and acclimation to changing environments. Chemically modifying molecular receptors and transducers of these signals is one way to efficiently induce proper physiological responses. Post-translation modifications, regulating protein biological activities, are central to many well-known signal-responding pathways. Recently, messenger RNA (mRNA) chemical (i.e. epitranscriptomic) modifications were also shown to play a key role in these processes. In contrast, transfer RNA (tRNA) and ribosomal RNA (rRNA) chemical modifications, although critical for optimal function of the translation apparatus, and much more diverse and quantitatively important compared to mRNA modifications, were until recently considered as mainly static chemical decorations. We present here recent observations that are challenging this view and supporting the hypothesis that tRNA and rRNA modifications dynamically respond to various cell and environmental conditions and contribute to adapt translation to these conditions.
format Online
Article
Text
id pubmed-8677040
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-86770402022-02-07 Variations in transfer and ribosomal RNA epitranscriptomic status can adapt eukaryote translation to changing physiological and environmental conditions Dannfald, Arnaud Favory, Jean-Jacques Deragon, Jean-Marc RNA Biol Review The timely reprogramming of gene expression in response to internal and external cues is essential to eukaryote development and acclimation to changing environments. Chemically modifying molecular receptors and transducers of these signals is one way to efficiently induce proper physiological responses. Post-translation modifications, regulating protein biological activities, are central to many well-known signal-responding pathways. Recently, messenger RNA (mRNA) chemical (i.e. epitranscriptomic) modifications were also shown to play a key role in these processes. In contrast, transfer RNA (tRNA) and ribosomal RNA (rRNA) chemical modifications, although critical for optimal function of the translation apparatus, and much more diverse and quantitatively important compared to mRNA modifications, were until recently considered as mainly static chemical decorations. We present here recent observations that are challenging this view and supporting the hypothesis that tRNA and rRNA modifications dynamically respond to various cell and environmental conditions and contribute to adapt translation to these conditions. Taylor & Francis 2021-06-23 /pmc/articles/PMC8677040/ /pubmed/34159889 http://dx.doi.org/10.1080/15476286.2021.1931756 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Dannfald, Arnaud
Favory, Jean-Jacques
Deragon, Jean-Marc
Variations in transfer and ribosomal RNA epitranscriptomic status can adapt eukaryote translation to changing physiological and environmental conditions
title Variations in transfer and ribosomal RNA epitranscriptomic status can adapt eukaryote translation to changing physiological and environmental conditions
title_full Variations in transfer and ribosomal RNA epitranscriptomic status can adapt eukaryote translation to changing physiological and environmental conditions
title_fullStr Variations in transfer and ribosomal RNA epitranscriptomic status can adapt eukaryote translation to changing physiological and environmental conditions
title_full_unstemmed Variations in transfer and ribosomal RNA epitranscriptomic status can adapt eukaryote translation to changing physiological and environmental conditions
title_short Variations in transfer and ribosomal RNA epitranscriptomic status can adapt eukaryote translation to changing physiological and environmental conditions
title_sort variations in transfer and ribosomal rna epitranscriptomic status can adapt eukaryote translation to changing physiological and environmental conditions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677040/
https://www.ncbi.nlm.nih.gov/pubmed/34159889
http://dx.doi.org/10.1080/15476286.2021.1931756
work_keys_str_mv AT dannfaldarnaud variationsintransferandribosomalrnaepitranscriptomicstatuscanadapteukaryotetranslationtochangingphysiologicalandenvironmentalconditions
AT favoryjeanjacques variationsintransferandribosomalrnaepitranscriptomicstatuscanadapteukaryotetranslationtochangingphysiologicalandenvironmentalconditions
AT deragonjeanmarc variationsintransferandribosomalrnaepitranscriptomicstatuscanadapteukaryotetranslationtochangingphysiologicalandenvironmentalconditions