Interplays of different types of epitranscriptomic mRNA modifications

Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m(6)A and ADAR RNA editing...

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Autores principales: Rengaraj, Praveenkumar, Obrdlík, Aleš, Vukić, Dragana, Varadarajan, Nandan Mysore, Keegan, Liam P., Vaňáčová, Štěpánka, O’Connell, Mary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677042/
https://www.ncbi.nlm.nih.gov/pubmed/34424827
http://dx.doi.org/10.1080/15476286.2021.1969113
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author Rengaraj, Praveenkumar
Obrdlík, Aleš
Vukić, Dragana
Varadarajan, Nandan Mysore
Keegan, Liam P.
Vaňáčová, Štěpánka
O’Connell, Mary A.
author_facet Rengaraj, Praveenkumar
Obrdlík, Aleš
Vukić, Dragana
Varadarajan, Nandan Mysore
Keegan, Liam P.
Vaňáčová, Štěpánka
O’Connell, Mary A.
author_sort Rengaraj, Praveenkumar
collection PubMed
description Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m(6)A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m(6)Am, m(5)C, m(1)A and Ψ and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.
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spelling pubmed-86770422022-02-07 Interplays of different types of epitranscriptomic mRNA modifications Rengaraj, Praveenkumar Obrdlík, Aleš Vukić, Dragana Varadarajan, Nandan Mysore Keegan, Liam P. Vaňáčová, Štěpánka O’Connell, Mary A. RNA Biol Review Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m(6)A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m(6)Am, m(5)C, m(1)A and Ψ and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences. Taylor & Francis 2021-08-23 /pmc/articles/PMC8677042/ /pubmed/34424827 http://dx.doi.org/10.1080/15476286.2021.1969113 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Rengaraj, Praveenkumar
Obrdlík, Aleš
Vukić, Dragana
Varadarajan, Nandan Mysore
Keegan, Liam P.
Vaňáčová, Štěpánka
O’Connell, Mary A.
Interplays of different types of epitranscriptomic mRNA modifications
title Interplays of different types of epitranscriptomic mRNA modifications
title_full Interplays of different types of epitranscriptomic mRNA modifications
title_fullStr Interplays of different types of epitranscriptomic mRNA modifications
title_full_unstemmed Interplays of different types of epitranscriptomic mRNA modifications
title_short Interplays of different types of epitranscriptomic mRNA modifications
title_sort interplays of different types of epitranscriptomic mrna modifications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677042/
https://www.ncbi.nlm.nih.gov/pubmed/34424827
http://dx.doi.org/10.1080/15476286.2021.1969113
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