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Therapeutic Effect of Seawater Pearl Powder on UV-Induced Photoaging in Mouse Skin

The objective of this study was to investigate the therapeutic effect of seawater pearl powder (SPP) on ultraviolet (UV) irradiation-induced photoaging in mouse skin. The protein and trace elements in SPP were detected by liquid chromatography-mass spectrometry, atomic fluorescence spectrometry, and...

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Autores principales: Han, Siyin, Huang, Delun, Lan, Taijin, Wu, Yongpei, Wang, Yingbiao, Wei, Jiying, Zhang, Weiyuan, Ou, Yuanyang, Yan, Qiangqiang, Liu, Peng, Chen, Zhenxing, Lin, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677389/
https://www.ncbi.nlm.nih.gov/pubmed/34925534
http://dx.doi.org/10.1155/2021/9516427
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author Han, Siyin
Huang, Delun
Lan, Taijin
Wu, Yongpei
Wang, Yingbiao
Wei, Jiying
Zhang, Weiyuan
Ou, Yuanyang
Yan, Qiangqiang
Liu, Peng
Chen, Zhenxing
Lin, Jiang
author_facet Han, Siyin
Huang, Delun
Lan, Taijin
Wu, Yongpei
Wang, Yingbiao
Wei, Jiying
Zhang, Weiyuan
Ou, Yuanyang
Yan, Qiangqiang
Liu, Peng
Chen, Zhenxing
Lin, Jiang
author_sort Han, Siyin
collection PubMed
description The objective of this study was to investigate the therapeutic effect of seawater pearl powder (SPP) on ultraviolet (UV) irradiation-induced photoaging in mouse skin. The protein and trace elements in SPP were detected by liquid chromatography-mass spectrometry, atomic fluorescence spectrometry, and inductively coupled plasma-atomic emission spectrometry. The effect of SPP on treating skin damage resulting from UV-induced photoaging was observed by gross physical appearance and histopathological analysis. Oxidative stress and melanin synthesis were analyzed using biochemical method. Western blotting was applied to analyze the phosphorylation and expression levels of matrix metalloproteinase-1 (MMP-1), collagen I, and proteins involved in the mitogen-activated protein kinase (MAPK) signaling pathways (p38, ERK, and JNK). The results show that SPP has a significant therapeutic effect on UV-induced photoaging of skin and improves and restores appearance and tissue structure of mouse skin. The major mechanism may be related to reduction of expression level of MMP-1 and enhancement of collagen I production via inhibition of MAPK signaling pathway after scavenging of excess reactive oxygen species (ROS) in the UV-induced photoaged skin of mice. Meanwhile, it may also be involved in reducing melanin content by inhibiting tyrosinase activity after scavenging excess ROS in the UV-induced photoaged skin of mice. Therefore, SPP could be a good substance to treat photoaging skin. Taking cost-effectiveness and efficacy into consideration, the optimal concentration of SPP for treating photoaging skin could be 100 mg/g.
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spelling pubmed-86773892021-12-17 Therapeutic Effect of Seawater Pearl Powder on UV-Induced Photoaging in Mouse Skin Han, Siyin Huang, Delun Lan, Taijin Wu, Yongpei Wang, Yingbiao Wei, Jiying Zhang, Weiyuan Ou, Yuanyang Yan, Qiangqiang Liu, Peng Chen, Zhenxing Lin, Jiang Evid Based Complement Alternat Med Research Article The objective of this study was to investigate the therapeutic effect of seawater pearl powder (SPP) on ultraviolet (UV) irradiation-induced photoaging in mouse skin. The protein and trace elements in SPP were detected by liquid chromatography-mass spectrometry, atomic fluorescence spectrometry, and inductively coupled plasma-atomic emission spectrometry. The effect of SPP on treating skin damage resulting from UV-induced photoaging was observed by gross physical appearance and histopathological analysis. Oxidative stress and melanin synthesis were analyzed using biochemical method. Western blotting was applied to analyze the phosphorylation and expression levels of matrix metalloproteinase-1 (MMP-1), collagen I, and proteins involved in the mitogen-activated protein kinase (MAPK) signaling pathways (p38, ERK, and JNK). The results show that SPP has a significant therapeutic effect on UV-induced photoaging of skin and improves and restores appearance and tissue structure of mouse skin. The major mechanism may be related to reduction of expression level of MMP-1 and enhancement of collagen I production via inhibition of MAPK signaling pathway after scavenging of excess reactive oxygen species (ROS) in the UV-induced photoaged skin of mice. Meanwhile, it may also be involved in reducing melanin content by inhibiting tyrosinase activity after scavenging excess ROS in the UV-induced photoaged skin of mice. Therefore, SPP could be a good substance to treat photoaging skin. Taking cost-effectiveness and efficacy into consideration, the optimal concentration of SPP for treating photoaging skin could be 100 mg/g. Hindawi 2021-12-09 /pmc/articles/PMC8677389/ /pubmed/34925534 http://dx.doi.org/10.1155/2021/9516427 Text en Copyright © 2021 Siyin Han et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Han, Siyin
Huang, Delun
Lan, Taijin
Wu, Yongpei
Wang, Yingbiao
Wei, Jiying
Zhang, Weiyuan
Ou, Yuanyang
Yan, Qiangqiang
Liu, Peng
Chen, Zhenxing
Lin, Jiang
Therapeutic Effect of Seawater Pearl Powder on UV-Induced Photoaging in Mouse Skin
title Therapeutic Effect of Seawater Pearl Powder on UV-Induced Photoaging in Mouse Skin
title_full Therapeutic Effect of Seawater Pearl Powder on UV-Induced Photoaging in Mouse Skin
title_fullStr Therapeutic Effect of Seawater Pearl Powder on UV-Induced Photoaging in Mouse Skin
title_full_unstemmed Therapeutic Effect of Seawater Pearl Powder on UV-Induced Photoaging in Mouse Skin
title_short Therapeutic Effect of Seawater Pearl Powder on UV-Induced Photoaging in Mouse Skin
title_sort therapeutic effect of seawater pearl powder on uv-induced photoaging in mouse skin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677389/
https://www.ncbi.nlm.nih.gov/pubmed/34925534
http://dx.doi.org/10.1155/2021/9516427
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