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Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment

Delivering bioactive compounds into skin tissue has long been a challenge. Using ex vivo porcine and rat skins, here we demonstrate that a detachable dissolvable microneedle (DDMN) array, a special dissolvable microneedle that allows needle detachment from the base within 2 min post administration,...

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Autores principales: Sawutdeechaikul, Pritsana, Kanokrungsee, Silada, Sahaspot, Thanyapat, Thadvibun, Kamonwan, Banlunara, Wijit, Limcharoen, Benchaphorn, Sansureerungsikul, Titiporn, Rutwaree, Teeranut, Oungeun, Miranda, Wanichwecharungruang, Supason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677736/
https://www.ncbi.nlm.nih.gov/pubmed/34916571
http://dx.doi.org/10.1038/s41598-021-03503-5
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author Sawutdeechaikul, Pritsana
Kanokrungsee, Silada
Sahaspot, Thanyapat
Thadvibun, Kamonwan
Banlunara, Wijit
Limcharoen, Benchaphorn
Sansureerungsikul, Titiporn
Rutwaree, Teeranut
Oungeun, Miranda
Wanichwecharungruang, Supason
author_facet Sawutdeechaikul, Pritsana
Kanokrungsee, Silada
Sahaspot, Thanyapat
Thadvibun, Kamonwan
Banlunara, Wijit
Limcharoen, Benchaphorn
Sansureerungsikul, Titiporn
Rutwaree, Teeranut
Oungeun, Miranda
Wanichwecharungruang, Supason
author_sort Sawutdeechaikul, Pritsana
collection PubMed
description Delivering bioactive compounds into skin tissue has long been a challenge. Using ex vivo porcine and rat skins, here we demonstrate that a detachable dissolvable microneedle (DDMN) array, a special dissolvable microneedle that allows needle detachment from the base within 2 min post administration, can effectively embed a model compound into epidermis and dermis. Diffusion of the compound from the needle embedding sites to the nearby skin tissue is demonstrated at various post administration periods. The relationship between the time that a conventional dissolvable microneedle array is left on skin without needle detachment from the base and the degree of skin surface abrasion at each microneedle penetration spot is also demonstrated on skin of human volunteers. Co-loading glutathione with vitamin C (vitC) can stabilize vitC in the DDMN. DDMN loaded with vitC and glutathione can help erasing post-acne-hyperpigmentation spots.
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spelling pubmed-86777362021-12-20 Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment Sawutdeechaikul, Pritsana Kanokrungsee, Silada Sahaspot, Thanyapat Thadvibun, Kamonwan Banlunara, Wijit Limcharoen, Benchaphorn Sansureerungsikul, Titiporn Rutwaree, Teeranut Oungeun, Miranda Wanichwecharungruang, Supason Sci Rep Article Delivering bioactive compounds into skin tissue has long been a challenge. Using ex vivo porcine and rat skins, here we demonstrate that a detachable dissolvable microneedle (DDMN) array, a special dissolvable microneedle that allows needle detachment from the base within 2 min post administration, can effectively embed a model compound into epidermis and dermis. Diffusion of the compound from the needle embedding sites to the nearby skin tissue is demonstrated at various post administration periods. The relationship between the time that a conventional dissolvable microneedle array is left on skin without needle detachment from the base and the degree of skin surface abrasion at each microneedle penetration spot is also demonstrated on skin of human volunteers. Co-loading glutathione with vitamin C (vitC) can stabilize vitC in the DDMN. DDMN loaded with vitC and glutathione can help erasing post-acne-hyperpigmentation spots. Nature Publishing Group UK 2021-12-16 /pmc/articles/PMC8677736/ /pubmed/34916571 http://dx.doi.org/10.1038/s41598-021-03503-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sawutdeechaikul, Pritsana
Kanokrungsee, Silada
Sahaspot, Thanyapat
Thadvibun, Kamonwan
Banlunara, Wijit
Limcharoen, Benchaphorn
Sansureerungsikul, Titiporn
Rutwaree, Teeranut
Oungeun, Miranda
Wanichwecharungruang, Supason
Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment
title Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment
title_full Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment
title_fullStr Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment
title_full_unstemmed Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment
title_short Detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment
title_sort detachable dissolvable microneedles: intra-epidermal and intradermal diffusion, effect on skin surface, and application in hyperpigmentation treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677736/
https://www.ncbi.nlm.nih.gov/pubmed/34916571
http://dx.doi.org/10.1038/s41598-021-03503-5
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