Dopamine Neuron Challenge Test for early detection of Parkinson’s disease

Diagnosing Parkinson’s disease (PD) before the clinical onset proves difficult because the hallmark PD symptoms do not manifest until more than 60% of dopamine neurons in the substantia nigra pars compacta have been lost. Here we show that, by evoking a transient dopamine release and subsequently me...

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Autores principales: Zhou, Jingheng, Li, Jicheng, Papaneri, Amy B., Kobzar, Nicholas P., Cui, Guohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677804/
https://www.ncbi.nlm.nih.gov/pubmed/34916526
http://dx.doi.org/10.1038/s41531-021-00261-z
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author Zhou, Jingheng
Li, Jicheng
Papaneri, Amy B.
Kobzar, Nicholas P.
Cui, Guohong
author_facet Zhou, Jingheng
Li, Jicheng
Papaneri, Amy B.
Kobzar, Nicholas P.
Cui, Guohong
author_sort Zhou, Jingheng
collection PubMed
description Diagnosing Parkinson’s disease (PD) before the clinical onset proves difficult because the hallmark PD symptoms do not manifest until more than 60% of dopamine neurons in the substantia nigra pars compacta have been lost. Here we show that, by evoking a transient dopamine release and subsequently measuring the levels of dopamine metabolites in the cerebrospinal fluid and plasma, a hypodopaminergic state can be revealed when less than 30% of dopamine neurons are lost in mouse PD models. These findings may lead to sensitive and practical screening and diagnostic tests for detecting early PD in the high-risk population.
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spelling pubmed-86778042022-01-04 Dopamine Neuron Challenge Test for early detection of Parkinson’s disease Zhou, Jingheng Li, Jicheng Papaneri, Amy B. Kobzar, Nicholas P. Cui, Guohong NPJ Parkinsons Dis Article Diagnosing Parkinson’s disease (PD) before the clinical onset proves difficult because the hallmark PD symptoms do not manifest until more than 60% of dopamine neurons in the substantia nigra pars compacta have been lost. Here we show that, by evoking a transient dopamine release and subsequently measuring the levels of dopamine metabolites in the cerebrospinal fluid and plasma, a hypodopaminergic state can be revealed when less than 30% of dopamine neurons are lost in mouse PD models. These findings may lead to sensitive and practical screening and diagnostic tests for detecting early PD in the high-risk population. Nature Publishing Group UK 2021-12-16 /pmc/articles/PMC8677804/ /pubmed/34916526 http://dx.doi.org/10.1038/s41531-021-00261-z Text en © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhou, Jingheng
Li, Jicheng
Papaneri, Amy B.
Kobzar, Nicholas P.
Cui, Guohong
Dopamine Neuron Challenge Test for early detection of Parkinson’s disease
title Dopamine Neuron Challenge Test for early detection of Parkinson’s disease
title_full Dopamine Neuron Challenge Test for early detection of Parkinson’s disease
title_fullStr Dopamine Neuron Challenge Test for early detection of Parkinson’s disease
title_full_unstemmed Dopamine Neuron Challenge Test for early detection of Parkinson’s disease
title_short Dopamine Neuron Challenge Test for early detection of Parkinson’s disease
title_sort dopamine neuron challenge test for early detection of parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677804/
https://www.ncbi.nlm.nih.gov/pubmed/34916526
http://dx.doi.org/10.1038/s41531-021-00261-z
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