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RIG-I and MDA5 Protect Mice From Pichinde Virus Infection by Controlling Viral Replication and Regulating Immune Responses to the Infection

RIG-I and MDA5 are major cytoplasmic innate-immune sensor proteins that recognize aberrant double-stranded RNAs generated during virus infection to activate type 1 interferon (IFN-I) and IFN-stimulated gene (ISG) expressions to control virus infection. The roles of RIG-I and MDA5 in controlling repl...

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Detalles Bibliográficos
Autores principales:	Brisse, Morgan, Huang, Qinfeng, Rahman, Mizanur, Di, Da, Liang, Yuying, Ly, Hinh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677829/ https://www.ncbi.nlm.nih.gov/pubmed/34925387 http://dx.doi.org/10.3389/fimmu.2021.801811

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