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Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders
Metabolic disorders are an increasing concern in the industrialized world. Current research has shown a direct link between the composition of the gut microbiota and the pathogenesis of obesity and diabetes. In only a few weeks, an obesity-inducing diet can lead to increased gut permeability and mic...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677946/ https://www.ncbi.nlm.nih.gov/pubmed/34925006 http://dx.doi.org/10.3389/fphar.2021.740636 |
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author | Maioli, Tatiani Uceli Borras-Nogues, Esther Torres, Licia Barbosa, Sara Candida Martins, Vinicius Dantas Langella, Philippe Azevedo, Vasco Ariston Chatel, Jean-Marc |
author_facet | Maioli, Tatiani Uceli Borras-Nogues, Esther Torres, Licia Barbosa, Sara Candida Martins, Vinicius Dantas Langella, Philippe Azevedo, Vasco Ariston Chatel, Jean-Marc |
author_sort | Maioli, Tatiani Uceli |
collection | PubMed |
description | Metabolic disorders are an increasing concern in the industrialized world. Current research has shown a direct link between the composition of the gut microbiota and the pathogenesis of obesity and diabetes. In only a few weeks, an obesity-inducing diet can lead to increased gut permeability and microbial dysbiosis, which contributes to chronic inflammation in the gut and adipose tissues, and to the development of insulin resistance. In this review, we examine the interplay between gut inflammation, insulin resistance, and the gut microbiota, and discuss how some probiotic species can be used to modulate gut homeostasis. We focus primarily on Faecalibacterium prausnitzii, a highly abundant butyrate-producing bacterium that has been proposed both as a biomarker for the development of different gut pathologies and as a potential treatment due to its production of anti-inflammatory metabolites. |
format | Online Article Text |
id | pubmed-8677946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86779462021-12-18 Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders Maioli, Tatiani Uceli Borras-Nogues, Esther Torres, Licia Barbosa, Sara Candida Martins, Vinicius Dantas Langella, Philippe Azevedo, Vasco Ariston Chatel, Jean-Marc Front Pharmacol Pharmacology Metabolic disorders are an increasing concern in the industrialized world. Current research has shown a direct link between the composition of the gut microbiota and the pathogenesis of obesity and diabetes. In only a few weeks, an obesity-inducing diet can lead to increased gut permeability and microbial dysbiosis, which contributes to chronic inflammation in the gut and adipose tissues, and to the development of insulin resistance. In this review, we examine the interplay between gut inflammation, insulin resistance, and the gut microbiota, and discuss how some probiotic species can be used to modulate gut homeostasis. We focus primarily on Faecalibacterium prausnitzii, a highly abundant butyrate-producing bacterium that has been proposed both as a biomarker for the development of different gut pathologies and as a potential treatment due to its production of anti-inflammatory metabolites. Frontiers Media S.A. 2021-12-02 /pmc/articles/PMC8677946/ /pubmed/34925006 http://dx.doi.org/10.3389/fphar.2021.740636 Text en Copyright © 2021 Maioli, Borras-Nogues, Torres, Barbosa, Martins, Langella, Azevedo and Chatel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Maioli, Tatiani Uceli Borras-Nogues, Esther Torres, Licia Barbosa, Sara Candida Martins, Vinicius Dantas Langella, Philippe Azevedo, Vasco Ariston Chatel, Jean-Marc Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
title | Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
title_full | Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
title_fullStr | Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
title_full_unstemmed | Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
title_short | Possible Benefits of Faecalibacterium prausnitzii for Obesity-Associated Gut Disorders |
title_sort | possible benefits of faecalibacterium prausnitzii for obesity-associated gut disorders |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8677946/ https://www.ncbi.nlm.nih.gov/pubmed/34925006 http://dx.doi.org/10.3389/fphar.2021.740636 |
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