Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote C. elegans Longevity and Healthspan

Broccoli-derived isothiocyanate sulforaphane inhibits inflammation and cancer. Sulforaphane may support healthy aging, but the underlying detailed mechanisms are unclear. We used the C. elegans nematode model to address this question. Wild-type and 4 mutant C. elegans worm strains were fed in the pr...

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Detalles Bibliográficos
Autores principales: Ji, Huihui, Qi, Zhimin, Schrapel, Daniel, Le, Monika, Luo, Yiqiao, Yan, Bin, Gladkich, Jury, Schaefer, Michael, Liu, Li, Herr, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678450/
https://www.ncbi.nlm.nih.gov/pubmed/34926464
http://dx.doi.org/10.3389/fcell.2021.784999

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