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Benefits of vitamin D supplementation to attenuate TBI secondary injury?

Vitamin D supplementation has been shown to improve outcomes for patients suffering from a variety of illnesses such as stroke and cancer. Vitamin D deficiencies have been associated with longer hospital stays, greater severity of symptoms, and death in some complex cases. Due to vitamin D’s burgeon...

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Autores principales: Saadatmand, Kiana, Khan, Saba, Hassan, Quaratulain, Hautamaki, Raymond, Ashouri, Rani, Lua, Josh, Doré, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678475/
https://www.ncbi.nlm.nih.gov/pubmed/34992852
http://dx.doi.org/10.1515/tnsci-2020-0195
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author Saadatmand, Kiana
Khan, Saba
Hassan, Quaratulain
Hautamaki, Raymond
Ashouri, Rani
Lua, Josh
Doré, Sylvain
author_facet Saadatmand, Kiana
Khan, Saba
Hassan, Quaratulain
Hautamaki, Raymond
Ashouri, Rani
Lua, Josh
Doré, Sylvain
author_sort Saadatmand, Kiana
collection PubMed
description Vitamin D supplementation has been shown to improve outcomes for patients suffering from a variety of illnesses such as stroke and cancer. Vitamin D deficiencies have been associated with longer hospital stays, greater severity of symptoms, and death in some complex cases. Due to vitamin D’s burgeoning role in improving patient outcomes, a new sector of research is focusing on the lesser-known implications of vitamin D on health. Traumatic brain injury (TBI) affects approximately 69 million people worldwide per year. Here, we summarize the current scientific understanding of vitamin D dynamics with TBI to elucidate a potential way to lessen the cascade of secondary damage after an initial insult, with the goal of improving overall patient outcomes. Because vitamin D supplementation has been correlated with better outcomes in other pathologies involving immune and inflammatory molecules, it is important to study the potential effect of vitamin D deficiency (VDD) and supplementation on TBI outcomes. Research on vitamin D supplementation in TBI remains in the preliminary stages. There is still much to learn about vitamin D deficiency, dosage, variants of supplementary forms, mechanisms, and its role in TBI.
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spelling pubmed-86784752022-01-05 Benefits of vitamin D supplementation to attenuate TBI secondary injury? Saadatmand, Kiana Khan, Saba Hassan, Quaratulain Hautamaki, Raymond Ashouri, Rani Lua, Josh Doré, Sylvain Transl Neurosci Review Article Vitamin D supplementation has been shown to improve outcomes for patients suffering from a variety of illnesses such as stroke and cancer. Vitamin D deficiencies have been associated with longer hospital stays, greater severity of symptoms, and death in some complex cases. Due to vitamin D’s burgeoning role in improving patient outcomes, a new sector of research is focusing on the lesser-known implications of vitamin D on health. Traumatic brain injury (TBI) affects approximately 69 million people worldwide per year. Here, we summarize the current scientific understanding of vitamin D dynamics with TBI to elucidate a potential way to lessen the cascade of secondary damage after an initial insult, with the goal of improving overall patient outcomes. Because vitamin D supplementation has been correlated with better outcomes in other pathologies involving immune and inflammatory molecules, it is important to study the potential effect of vitamin D deficiency (VDD) and supplementation on TBI outcomes. Research on vitamin D supplementation in TBI remains in the preliminary stages. There is still much to learn about vitamin D deficiency, dosage, variants of supplementary forms, mechanisms, and its role in TBI. De Gruyter 2021-12-15 /pmc/articles/PMC8678475/ /pubmed/34992852 http://dx.doi.org/10.1515/tnsci-2020-0195 Text en © 2021 Kiana Saadatmand et al., published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Review Article
Saadatmand, Kiana
Khan, Saba
Hassan, Quaratulain
Hautamaki, Raymond
Ashouri, Rani
Lua, Josh
Doré, Sylvain
Benefits of vitamin D supplementation to attenuate TBI secondary injury?
title Benefits of vitamin D supplementation to attenuate TBI secondary injury?
title_full Benefits of vitamin D supplementation to attenuate TBI secondary injury?
title_fullStr Benefits of vitamin D supplementation to attenuate TBI secondary injury?
title_full_unstemmed Benefits of vitamin D supplementation to attenuate TBI secondary injury?
title_short Benefits of vitamin D supplementation to attenuate TBI secondary injury?
title_sort benefits of vitamin d supplementation to attenuate tbi secondary injury?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678475/
https://www.ncbi.nlm.nih.gov/pubmed/34992852
http://dx.doi.org/10.1515/tnsci-2020-0195
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