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Hearing loss and brain disorders: A review of multiple pathologies
Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literatu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678477/ https://www.ncbi.nlm.nih.gov/pubmed/34993346 http://dx.doi.org/10.1515/med-2021-0402 |
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author | Oluwole, Oluwafemi Gabriel James, Kili Yalcouye, Abdoulaye Wonkam, Ambroise |
author_facet | Oluwole, Oluwafemi Gabriel James, Kili Yalcouye, Abdoulaye Wonkam, Ambroise |
author_sort | Oluwole, Oluwafemi Gabriel |
collection | PubMed |
description | Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literature for published articles on HL and brain disorders. Alzheimer’s disease/dementia, Parkinson’s disease, cognitive impairment, autism spectrum disorder, ataxia, epilepsy, stroke, and hypoxic-ischaemic encephalopathy majorly co-interact with HL. The estimated incidence rate was 113 per 10,000 person-years. Genetic, epigenetic, early life/neonatal stress, hypoxia, inflammation, nitric oxide infiltration, endoplasmic reticulum stress, and excess glutamate were the distinguished modifiers identified. Various mechanisms like adhesion molecules, transport proteins, hair cell apoptosis, and neurodegeneration have been implicated in these conditions and are serving as potential targets for therapies. To improve the quality of life of patients, these understandings will improve clinical diagnoses and management of HL and brain disorders. |
format | Online Article Text |
id | pubmed-8678477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-86784772022-01-05 Hearing loss and brain disorders: A review of multiple pathologies Oluwole, Oluwafemi Gabriel James, Kili Yalcouye, Abdoulaye Wonkam, Ambroise Open Med (Wars) Review Article Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literature for published articles on HL and brain disorders. Alzheimer’s disease/dementia, Parkinson’s disease, cognitive impairment, autism spectrum disorder, ataxia, epilepsy, stroke, and hypoxic-ischaemic encephalopathy majorly co-interact with HL. The estimated incidence rate was 113 per 10,000 person-years. Genetic, epigenetic, early life/neonatal stress, hypoxia, inflammation, nitric oxide infiltration, endoplasmic reticulum stress, and excess glutamate were the distinguished modifiers identified. Various mechanisms like adhesion molecules, transport proteins, hair cell apoptosis, and neurodegeneration have been implicated in these conditions and are serving as potential targets for therapies. To improve the quality of life of patients, these understandings will improve clinical diagnoses and management of HL and brain disorders. De Gruyter 2021-12-15 /pmc/articles/PMC8678477/ /pubmed/34993346 http://dx.doi.org/10.1515/med-2021-0402 Text en © 2022 Oluwafemi Gabriel Oluwole et al., published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. |
spellingShingle | Review Article Oluwole, Oluwafemi Gabriel James, Kili Yalcouye, Abdoulaye Wonkam, Ambroise Hearing loss and brain disorders: A review of multiple pathologies |
title | Hearing loss and brain disorders: A review of multiple pathologies |
title_full | Hearing loss and brain disorders: A review of multiple pathologies |
title_fullStr | Hearing loss and brain disorders: A review of multiple pathologies |
title_full_unstemmed | Hearing loss and brain disorders: A review of multiple pathologies |
title_short | Hearing loss and brain disorders: A review of multiple pathologies |
title_sort | hearing loss and brain disorders: a review of multiple pathologies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678477/ https://www.ncbi.nlm.nih.gov/pubmed/34993346 http://dx.doi.org/10.1515/med-2021-0402 |
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