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Hearing loss and brain disorders: A review of multiple pathologies

Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literatu...

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Autores principales: Oluwole, Oluwafemi Gabriel, James, Kili, Yalcouye, Abdoulaye, Wonkam, Ambroise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678477/
https://www.ncbi.nlm.nih.gov/pubmed/34993346
http://dx.doi.org/10.1515/med-2021-0402
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author Oluwole, Oluwafemi Gabriel
James, Kili
Yalcouye, Abdoulaye
Wonkam, Ambroise
author_facet Oluwole, Oluwafemi Gabriel
James, Kili
Yalcouye, Abdoulaye
Wonkam, Ambroise
author_sort Oluwole, Oluwafemi Gabriel
collection PubMed
description Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literature for published articles on HL and brain disorders. Alzheimer’s disease/dementia, Parkinson’s disease, cognitive impairment, autism spectrum disorder, ataxia, epilepsy, stroke, and hypoxic-ischaemic encephalopathy majorly co-interact with HL. The estimated incidence rate was 113 per 10,000 person-years. Genetic, epigenetic, early life/neonatal stress, hypoxia, inflammation, nitric oxide infiltration, endoplasmic reticulum stress, and excess glutamate were the distinguished modifiers identified. Various mechanisms like adhesion molecules, transport proteins, hair cell apoptosis, and neurodegeneration have been implicated in these conditions and are serving as potential targets for therapies. To improve the quality of life of patients, these understandings will improve clinical diagnoses and management of HL and brain disorders.
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spelling pubmed-86784772022-01-05 Hearing loss and brain disorders: A review of multiple pathologies Oluwole, Oluwafemi Gabriel James, Kili Yalcouye, Abdoulaye Wonkam, Ambroise Open Med (Wars) Review Article Several causative factors are associated with hearing loss (HL) and brain disorders. However, there are many unidentified disease modifiers in these conditions. Our study summarised the most common brain disorders associated with HL and highlighted mechanisms of pathologies. We searched the literature for published articles on HL and brain disorders. Alzheimer’s disease/dementia, Parkinson’s disease, cognitive impairment, autism spectrum disorder, ataxia, epilepsy, stroke, and hypoxic-ischaemic encephalopathy majorly co-interact with HL. The estimated incidence rate was 113 per 10,000 person-years. Genetic, epigenetic, early life/neonatal stress, hypoxia, inflammation, nitric oxide infiltration, endoplasmic reticulum stress, and excess glutamate were the distinguished modifiers identified. Various mechanisms like adhesion molecules, transport proteins, hair cell apoptosis, and neurodegeneration have been implicated in these conditions and are serving as potential targets for therapies. To improve the quality of life of patients, these understandings will improve clinical diagnoses and management of HL and brain disorders. De Gruyter 2021-12-15 /pmc/articles/PMC8678477/ /pubmed/34993346 http://dx.doi.org/10.1515/med-2021-0402 Text en © 2022 Oluwafemi Gabriel Oluwole et al., published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Review Article
Oluwole, Oluwafemi Gabriel
James, Kili
Yalcouye, Abdoulaye
Wonkam, Ambroise
Hearing loss and brain disorders: A review of multiple pathologies
title Hearing loss and brain disorders: A review of multiple pathologies
title_full Hearing loss and brain disorders: A review of multiple pathologies
title_fullStr Hearing loss and brain disorders: A review of multiple pathologies
title_full_unstemmed Hearing loss and brain disorders: A review of multiple pathologies
title_short Hearing loss and brain disorders: A review of multiple pathologies
title_sort hearing loss and brain disorders: a review of multiple pathologies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678477/
https://www.ncbi.nlm.nih.gov/pubmed/34993346
http://dx.doi.org/10.1515/med-2021-0402
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