Function and Inhibitory Mechanisms of Multidrug Efflux Pumps

Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug efflux pumps exist in bacteria. Also, the co-...

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Autores principales: Nishino, Kunihiko, Yamasaki, Seiji, Nakashima, Ryosuke, Zwama, Martijn, Hayashi-Nishino, Mitsuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678522/
https://www.ncbi.nlm.nih.gov/pubmed/34925258
http://dx.doi.org/10.3389/fmicb.2021.737288
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author Nishino, Kunihiko
Yamasaki, Seiji
Nakashima, Ryosuke
Zwama, Martijn
Hayashi-Nishino, Mitsuko
author_facet Nishino, Kunihiko
Yamasaki, Seiji
Nakashima, Ryosuke
Zwama, Martijn
Hayashi-Nishino, Mitsuko
author_sort Nishino, Kunihiko
collection PubMed
description Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug efflux pumps exist in bacteria. Also, the co-crystal structural analysis of multidrug efflux pumps revealed the drug recognition and export mechanisms, and the inhibitory mechanisms of the pumps. A single multidrug efflux pump can export multiple antibiotics; hence, developing efflux pump inhibitors is crucial in overcoming infectious diseases caused by multidrug-resistant bacteria. This review article describes the role of multidrug efflux pumps in MDR, and their physiological functions and inhibitory mechanisms.
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spelling pubmed-86785222021-12-18 Function and Inhibitory Mechanisms of Multidrug Efflux Pumps Nishino, Kunihiko Yamasaki, Seiji Nakashima, Ryosuke Zwama, Martijn Hayashi-Nishino, Mitsuko Front Microbiol Microbiology Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug efflux pumps exist in bacteria. Also, the co-crystal structural analysis of multidrug efflux pumps revealed the drug recognition and export mechanisms, and the inhibitory mechanisms of the pumps. A single multidrug efflux pump can export multiple antibiotics; hence, developing efflux pump inhibitors is crucial in overcoming infectious diseases caused by multidrug-resistant bacteria. This review article describes the role of multidrug efflux pumps in MDR, and their physiological functions and inhibitory mechanisms. Frontiers Media S.A. 2021-12-03 /pmc/articles/PMC8678522/ /pubmed/34925258 http://dx.doi.org/10.3389/fmicb.2021.737288 Text en Copyright © 2021 Nishino, Yamasaki, Nakashima, Zwama and Hayashi-Nishino. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Nishino, Kunihiko
Yamasaki, Seiji
Nakashima, Ryosuke
Zwama, Martijn
Hayashi-Nishino, Mitsuko
Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
title Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
title_full Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
title_fullStr Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
title_full_unstemmed Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
title_short Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
title_sort function and inhibitory mechanisms of multidrug efflux pumps
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678522/
https://www.ncbi.nlm.nih.gov/pubmed/34925258
http://dx.doi.org/10.3389/fmicb.2021.737288
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