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Should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy?

It has long been known that blood pressure (BP) is characterized by marked short‐term fluctuations occurring within a 24‐h period and also by long‐term oscillations occurring over more prolonged periods of time. An increased short‐term blood pressure variability (BPV) appears to importantly contribu...

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Autores principales: Mulè’, Giuseppe, Sorce, Alessandra, Vario, Maria Giovanna, Giambrone, Marta, Cottone, Santina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678723/
https://www.ncbi.nlm.nih.gov/pubmed/33538054
http://dx.doi.org/10.1111/jch.14210
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author Mulè’, Giuseppe
Sorce, Alessandra
Vario, Maria Giovanna
Giambrone, Marta
Cottone, Santina
author_facet Mulè’, Giuseppe
Sorce, Alessandra
Vario, Maria Giovanna
Giambrone, Marta
Cottone, Santina
author_sort Mulè’, Giuseppe
collection PubMed
description It has long been known that blood pressure (BP) is characterized by marked short‐term fluctuations occurring within a 24‐h period and also by long‐term oscillations occurring over more prolonged periods of time. An increased short‐term blood pressure variability (BPV) appears to importantly contribute to target organ damage and to the enhanced cardiovascular risk of hypertensive patients, over and above the effect of an increase in mean BP levels. Reducing 24‐h mean BP is the main aim of antihypertensive therapy, but initial data are available that additional cardiovascular protection can be achieved by reducing BPV. However, to definitively prove the prognostic role of short‐term BPV and the need for its control by treatment, evidence is still needed from intervention trials aimed at demonstrating that by reducing BPV through administration of antihypertensive drugs, a reduction in organ damage and in the rate of cardiovascular events can be obtained.
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spelling pubmed-86787232021-12-23 Should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy? Mulè’, Giuseppe Sorce, Alessandra Vario, Maria Giovanna Giambrone, Marta Cottone, Santina J Clin Hypertens (Greenwich) Blood Pressure Variability It has long been known that blood pressure (BP) is characterized by marked short‐term fluctuations occurring within a 24‐h period and also by long‐term oscillations occurring over more prolonged periods of time. An increased short‐term blood pressure variability (BPV) appears to importantly contribute to target organ damage and to the enhanced cardiovascular risk of hypertensive patients, over and above the effect of an increase in mean BP levels. Reducing 24‐h mean BP is the main aim of antihypertensive therapy, but initial data are available that additional cardiovascular protection can be achieved by reducing BPV. However, to definitively prove the prognostic role of short‐term BPV and the need for its control by treatment, evidence is still needed from intervention trials aimed at demonstrating that by reducing BPV through administration of antihypertensive drugs, a reduction in organ damage and in the rate of cardiovascular events can be obtained. John Wiley and Sons Inc. 2021-02-04 /pmc/articles/PMC8678723/ /pubmed/33538054 http://dx.doi.org/10.1111/jch.14210 Text en © 2021 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Blood Pressure Variability
Mulè’, Giuseppe
Sorce, Alessandra
Vario, Maria Giovanna
Giambrone, Marta
Cottone, Santina
Should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy?
title Should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy?
title_full Should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy?
title_fullStr Should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy?
title_full_unstemmed Should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy?
title_short Should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy?
title_sort should reduction of increased short‐term blood pressure variability be a target of antihypertensive therapy?
topic Blood Pressure Variability
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678723/
https://www.ncbi.nlm.nih.gov/pubmed/33538054
http://dx.doi.org/10.1111/jch.14210
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