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Surveillance strategies for precancerous gastric conditions after Helicobacter pylori eradication: There is still need for a tailored approach

Prevailing evidence declares that Helicobacter pylori (H. pylori) eradication therapy could shift precancerous gastric conditions (PGC) and positively confines gastric cancer (GC) risk during long-term endoscopic follow-up. Nonetheless, there is a yet unsolved controversy regarding the best-individu...

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Autores principales: Shahini, Endrit, Maida, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678819/
https://www.ncbi.nlm.nih.gov/pubmed/35046629
http://dx.doi.org/10.3748/wjg.v27.i46.8033
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author Shahini, Endrit
Maida, Marcello
author_facet Shahini, Endrit
Maida, Marcello
author_sort Shahini, Endrit
collection PubMed
description Prevailing evidence declares that Helicobacter pylori (H. pylori) eradication therapy could shift precancerous gastric conditions (PGC) and positively confines gastric cancer (GC) risk during long-term endoscopic follow-up. Nonetheless, there is a yet unsolved controversy regarding the best-individualized surveillance strategies following H. pylori eradication, based on malignant risk stratification. This last dispute is due to the uncertainty of contemporary evidence and the role of H. pylori inflammatory changes in underestimating PGC at the index endoscopy. However, the current state of the art suggests that it is reasonable that high-quality endoscopy with histological assessment for the most accurate diagnosis of PGC may be delayed in selected high-risk patients without alarm signs for malignancy, following the eradication of H. pylori. Notwithstanding, these aspects need to be further examined in the next future to establish and optimize the most beneficial and cost-effective strategies for recognizing and managing H. pylori-positive patients with PGC in the short- and long-term follow-up. Accordingly, additional studies are yet required to sharpen the hazard stratification of patients with the greatest chance of GC evolution, also recognizing the evolving racial, ethnic, immigration factors and the necessity of novel biomarkers to limit GC development or accomplish a diagnosis of malignancy at an early stage.
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spelling pubmed-86788192022-01-18 Surveillance strategies for precancerous gastric conditions after Helicobacter pylori eradication: There is still need for a tailored approach Shahini, Endrit Maida, Marcello World J Gastroenterol Letter to the Editor Prevailing evidence declares that Helicobacter pylori (H. pylori) eradication therapy could shift precancerous gastric conditions (PGC) and positively confines gastric cancer (GC) risk during long-term endoscopic follow-up. Nonetheless, there is a yet unsolved controversy regarding the best-individualized surveillance strategies following H. pylori eradication, based on malignant risk stratification. This last dispute is due to the uncertainty of contemporary evidence and the role of H. pylori inflammatory changes in underestimating PGC at the index endoscopy. However, the current state of the art suggests that it is reasonable that high-quality endoscopy with histological assessment for the most accurate diagnosis of PGC may be delayed in selected high-risk patients without alarm signs for malignancy, following the eradication of H. pylori. Notwithstanding, these aspects need to be further examined in the next future to establish and optimize the most beneficial and cost-effective strategies for recognizing and managing H. pylori-positive patients with PGC in the short- and long-term follow-up. Accordingly, additional studies are yet required to sharpen the hazard stratification of patients with the greatest chance of GC evolution, also recognizing the evolving racial, ethnic, immigration factors and the necessity of novel biomarkers to limit GC development or accomplish a diagnosis of malignancy at an early stage. Baishideng Publishing Group Inc 2021-12-14 2021-12-14 /pmc/articles/PMC8678819/ /pubmed/35046629 http://dx.doi.org/10.3748/wjg.v27.i46.8033 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Letter to the Editor
Shahini, Endrit
Maida, Marcello
Surveillance strategies for precancerous gastric conditions after Helicobacter pylori eradication: There is still need for a tailored approach
title Surveillance strategies for precancerous gastric conditions after Helicobacter pylori eradication: There is still need for a tailored approach
title_full Surveillance strategies for precancerous gastric conditions after Helicobacter pylori eradication: There is still need for a tailored approach
title_fullStr Surveillance strategies for precancerous gastric conditions after Helicobacter pylori eradication: There is still need for a tailored approach
title_full_unstemmed Surveillance strategies for precancerous gastric conditions after Helicobacter pylori eradication: There is still need for a tailored approach
title_short Surveillance strategies for precancerous gastric conditions after Helicobacter pylori eradication: There is still need for a tailored approach
title_sort surveillance strategies for precancerous gastric conditions after helicobacter pylori eradication: there is still need for a tailored approach
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678819/
https://www.ncbi.nlm.nih.gov/pubmed/35046629
http://dx.doi.org/10.3748/wjg.v27.i46.8033
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