Cargando…

Age‐related alterations in cardiac and arterial structure and function in hypertensive women and men

The study was to compare age‐related alterations in cardiac and arterial structure and function by sex and to explore the impacts of achieved systolic blood pressure (SBP; <130 mm Hg vs. <140 mm Hg) level on age‐related alterations in cardiac and arterial structure and function in hypertensive...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Anping, Zhou, Dan, Liu, Lin, Zhou, Yingling, Tang, Songtao, Feng, Yingqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678835/
https://www.ncbi.nlm.nih.gov/pubmed/33960629
http://dx.doi.org/10.1111/jch.14262
_version_ 1784616393013985280
author Cai, Anping
Zhou, Dan
Liu, Lin
Zhou, Yingling
Tang, Songtao
Feng, Yingqing
author_facet Cai, Anping
Zhou, Dan
Liu, Lin
Zhou, Yingling
Tang, Songtao
Feng, Yingqing
author_sort Cai, Anping
collection PubMed
description The study was to compare age‐related alterations in cardiac and arterial structure and function by sex and to explore the impacts of achieved systolic blood pressure (SBP; <130 mm Hg vs. <140 mm Hg) level on age‐related alterations in cardiac and arterial structure and function in hypertensive women and men. Community hypertensive individuals without cardiovascular disease who had echocardiographic examination were included. Age‐related alterations in cardiac and arterial structure and function were compared by sex, and interplay between age and sex was analyzed according to achieved SBP level. The mean age of the cohort was 66.5 years, and women accounted for 62% (n = 602) of the cohort (n = 971). Compared to men, women had worse left ventricular (LV) diastolic function and greater LV and arterial stiffness. After adjusting for covariates, the magnitude of the associations between age with septal E/e′ ratio, septal S′ velocity, effective arterial elastance (Ea) and LV end‐diastolic elastance (Eed) were greater in women. Sex differences in the magnitude of association between age with these four indices varied according to achieved SBP level. When achieved SBP <130 mm Hg, the magnitude of the associations between age with septal E/e′ ratio, septal S′ velocity, Ea and Eed did not differ by sex. Since age and sex are non‐modifiable, achieving SBP target, especially at a lower level, might be beneficial to attenuate sex differences in age‐related alterations in cardiac and arterial structure and function.
format Online
Article
Text
id pubmed-8678835
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-86788352021-12-23 Age‐related alterations in cardiac and arterial structure and function in hypertensive women and men Cai, Anping Zhou, Dan Liu, Lin Zhou, Yingling Tang, Songtao Feng, Yingqing J Clin Hypertens (Greenwich) Target Organ Damage The study was to compare age‐related alterations in cardiac and arterial structure and function by sex and to explore the impacts of achieved systolic blood pressure (SBP; <130 mm Hg vs. <140 mm Hg) level on age‐related alterations in cardiac and arterial structure and function in hypertensive women and men. Community hypertensive individuals without cardiovascular disease who had echocardiographic examination were included. Age‐related alterations in cardiac and arterial structure and function were compared by sex, and interplay between age and sex was analyzed according to achieved SBP level. The mean age of the cohort was 66.5 years, and women accounted for 62% (n = 602) of the cohort (n = 971). Compared to men, women had worse left ventricular (LV) diastolic function and greater LV and arterial stiffness. After adjusting for covariates, the magnitude of the associations between age with septal E/e′ ratio, septal S′ velocity, effective arterial elastance (Ea) and LV end‐diastolic elastance (Eed) were greater in women. Sex differences in the magnitude of association between age with these four indices varied according to achieved SBP level. When achieved SBP <130 mm Hg, the magnitude of the associations between age with septal E/e′ ratio, septal S′ velocity, Ea and Eed did not differ by sex. Since age and sex are non‐modifiable, achieving SBP target, especially at a lower level, might be beneficial to attenuate sex differences in age‐related alterations in cardiac and arterial structure and function. John Wiley and Sons Inc. 2021-05-07 /pmc/articles/PMC8678835/ /pubmed/33960629 http://dx.doi.org/10.1111/jch.14262 Text en © 2021 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Target Organ Damage
Cai, Anping
Zhou, Dan
Liu, Lin
Zhou, Yingling
Tang, Songtao
Feng, Yingqing
Age‐related alterations in cardiac and arterial structure and function in hypertensive women and men
title Age‐related alterations in cardiac and arterial structure and function in hypertensive women and men
title_full Age‐related alterations in cardiac and arterial structure and function in hypertensive women and men
title_fullStr Age‐related alterations in cardiac and arterial structure and function in hypertensive women and men
title_full_unstemmed Age‐related alterations in cardiac and arterial structure and function in hypertensive women and men
title_short Age‐related alterations in cardiac and arterial structure and function in hypertensive women and men
title_sort age‐related alterations in cardiac and arterial structure and function in hypertensive women and men
topic Target Organ Damage
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678835/
https://www.ncbi.nlm.nih.gov/pubmed/33960629
http://dx.doi.org/10.1111/jch.14262
work_keys_str_mv AT caianping agerelatedalterationsincardiacandarterialstructureandfunctioninhypertensivewomenandmen
AT zhoudan agerelatedalterationsincardiacandarterialstructureandfunctioninhypertensivewomenandmen
AT liulin agerelatedalterationsincardiacandarterialstructureandfunctioninhypertensivewomenandmen
AT zhouyingling agerelatedalterationsincardiacandarterialstructureandfunctioninhypertensivewomenandmen
AT tangsongtao agerelatedalterationsincardiacandarterialstructureandfunctioninhypertensivewomenandmen
AT fengyingqing agerelatedalterationsincardiacandarterialstructureandfunctioninhypertensivewomenandmen