Cargando…
Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry With High Myopia
IMPORTANCE: High myopia incidence and prevalence is increasing worldwide, and the visual burden caused by myopia is expected to rise accordingly. Studies investigating the occurrence of myopic complications in individuals of European ancestry with high myopia are scarce, hampering insights into the...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Medical Association
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678902/ https://www.ncbi.nlm.nih.gov/pubmed/34913968 http://dx.doi.org/10.1001/jamaophthalmol.2021.5346 |
_version_ | 1784616406977871872 |
---|---|
author | Haarman, Annechien E. G. Tedja, Milly S. Brussee, Corina Enthoven, Clair A. van Rijn, Gwyneth A. Vingerling, Johannes R. Keunen, Jan E. E. Boon, Camiel J. F. Geerards, Annette J. M. Luyten, Gré P. M. Verhoeven, Virginie J. M. Klaver, Caroline C. W. |
author_facet | Haarman, Annechien E. G. Tedja, Milly S. Brussee, Corina Enthoven, Clair A. van Rijn, Gwyneth A. Vingerling, Johannes R. Keunen, Jan E. E. Boon, Camiel J. F. Geerards, Annette J. M. Luyten, Gré P. M. Verhoeven, Virginie J. M. Klaver, Caroline C. W. |
author_sort | Haarman, Annechien E. G. |
collection | PubMed |
description | IMPORTANCE: High myopia incidence and prevalence is increasing worldwide, and the visual burden caused by myopia is expected to rise accordingly. Studies investigating the occurrence of myopic complications in individuals of European ancestry with high myopia are scarce, hampering insights into the frequency of myopic retinal complications in European individuals and their visual burden. OBJECTIVE: To assess the frequency of myopic macular features in individuals of European ancestry with high myopia. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional analysis of the Dutch Myopia Study (MYST) and individuals with high myopia from the Rotterdam Study (RS) included 626 patients with high myopia (spherical equivalent of refractive error [SER] ≤−6 diopters [D] or axial length [AL] ≥26 mm) who underwent an extensive ophthalmic examination including multimodal retinal imaging. In addition to this combination of a population-based cohort study and mix-based high myopia study, a systematic literature review was also performed to compare findings with studies of individuals of Asian ancestry. EXPOSURES: High myopia, age, and AL. MAIN OUTCOMES AND MEASURES: Frequency of myopic macular and optic disc features: tessellated fundus, myopic macular degeneration (MMD), staphyloma, peripapillary intrachoroidal cavitation, peripapillary atrophy (PPA), and “plus” lesions (choroidal neovascularization, Fuchs spot, and lacquer cracks). RESULTS: The mean (SD) SER of the combined study population (MYST and RS) was −9.9 (3.2) D; the mean (SD) age was 51.4 (15.1) years, and 387 (61.8%) were women. The prevalence of MMD was 25.9% and increased with older age (P for trend <.001), lower SER (odds ratio [OR], 0.70; 95% CI, 0.65-0.76; P < .001), and higher AL (OR, 2.53; 95% CI, 2.13-3.06; P < .001). Choroidal neovascularization or Fuchs spot was present in 2.7% (n = 17), both lesions in 0.3% (n = 2), and lacquer cracks in 1.4% (n = 9). Staphyloma, PPA, and MMD were highly prevalent in visual impaired and blind eyes (frequency was 73.9% [20 of 27], 90.5% [19 of 21], and 63.0% [17 of 27] of unilateral blind eyes for MMD, staphyloma, and PPA, respectively). Seven previous studies in Asian populations reported a variable MMD frequency ranging from 8.3% to 64%, but frequencies were similar for comparable risk profiles based on age and SER. CONCLUSIONS AND RELEVANCE: In this cross-sectional study of a highly myopic Dutch population of European ancestry, myopic retinal features were frequent; were associated with age, SER, and AL; and occurred in all visually severely impaired eyes. The absence of treatment options for most of these retinal complications emphasizes the need for effective strategies to prevent high myopia. |
format | Online Article Text |
id | pubmed-8678902 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Medical Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-86789022022-01-04 Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry With High Myopia Haarman, Annechien E. G. Tedja, Milly S. Brussee, Corina Enthoven, Clair A. van Rijn, Gwyneth A. Vingerling, Johannes R. Keunen, Jan E. E. Boon, Camiel J. F. Geerards, Annette J. M. Luyten, Gré P. M. Verhoeven, Virginie J. M. Klaver, Caroline C. W. JAMA Ophthalmol Original Investigation IMPORTANCE: High myopia incidence and prevalence is increasing worldwide, and the visual burden caused by myopia is expected to rise accordingly. Studies investigating the occurrence of myopic complications in individuals of European ancestry with high myopia are scarce, hampering insights into the frequency of myopic retinal complications in European individuals and their visual burden. OBJECTIVE: To assess the frequency of myopic macular features in individuals of European ancestry with high myopia. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional analysis of the Dutch Myopia Study (MYST) and individuals with high myopia from the Rotterdam Study (RS) included 626 patients with high myopia (spherical equivalent of refractive error [SER] ≤−6 diopters [D] or axial length [AL] ≥26 mm) who underwent an extensive ophthalmic examination including multimodal retinal imaging. In addition to this combination of a population-based cohort study and mix-based high myopia study, a systematic literature review was also performed to compare findings with studies of individuals of Asian ancestry. EXPOSURES: High myopia, age, and AL. MAIN OUTCOMES AND MEASURES: Frequency of myopic macular and optic disc features: tessellated fundus, myopic macular degeneration (MMD), staphyloma, peripapillary intrachoroidal cavitation, peripapillary atrophy (PPA), and “plus” lesions (choroidal neovascularization, Fuchs spot, and lacquer cracks). RESULTS: The mean (SD) SER of the combined study population (MYST and RS) was −9.9 (3.2) D; the mean (SD) age was 51.4 (15.1) years, and 387 (61.8%) were women. The prevalence of MMD was 25.9% and increased with older age (P for trend <.001), lower SER (odds ratio [OR], 0.70; 95% CI, 0.65-0.76; P < .001), and higher AL (OR, 2.53; 95% CI, 2.13-3.06; P < .001). Choroidal neovascularization or Fuchs spot was present in 2.7% (n = 17), both lesions in 0.3% (n = 2), and lacquer cracks in 1.4% (n = 9). Staphyloma, PPA, and MMD were highly prevalent in visual impaired and blind eyes (frequency was 73.9% [20 of 27], 90.5% [19 of 21], and 63.0% [17 of 27] of unilateral blind eyes for MMD, staphyloma, and PPA, respectively). Seven previous studies in Asian populations reported a variable MMD frequency ranging from 8.3% to 64%, but frequencies were similar for comparable risk profiles based on age and SER. CONCLUSIONS AND RELEVANCE: In this cross-sectional study of a highly myopic Dutch population of European ancestry, myopic retinal features were frequent; were associated with age, SER, and AL; and occurred in all visually severely impaired eyes. The absence of treatment options for most of these retinal complications emphasizes the need for effective strategies to prevent high myopia. American Medical Association 2021-12-16 2022-02 /pmc/articles/PMC8678902/ /pubmed/34913968 http://dx.doi.org/10.1001/jamaophthalmol.2021.5346 Text en Copyright 2021 Haarman AEG et al. JAMA Ophthalmology. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the CC-BY License. |
spellingShingle | Original Investigation Haarman, Annechien E. G. Tedja, Milly S. Brussee, Corina Enthoven, Clair A. van Rijn, Gwyneth A. Vingerling, Johannes R. Keunen, Jan E. E. Boon, Camiel J. F. Geerards, Annette J. M. Luyten, Gré P. M. Verhoeven, Virginie J. M. Klaver, Caroline C. W. Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry With High Myopia |
title | Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry With High Myopia |
title_full | Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry With High Myopia |
title_fullStr | Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry With High Myopia |
title_full_unstemmed | Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry With High Myopia |
title_short | Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry With High Myopia |
title_sort | prevalence of myopic macular features in dutch individuals of european ancestry with high myopia |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678902/ https://www.ncbi.nlm.nih.gov/pubmed/34913968 http://dx.doi.org/10.1001/jamaophthalmol.2021.5346 |
work_keys_str_mv | AT haarmanannechieneg prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia AT tedjamillys prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia AT brusseecorina prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia AT enthovenclaira prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia AT vanrijngwynetha prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia AT vingerlingjohannesr prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia AT keunenjanee prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia AT booncamieljf prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia AT geerardsannettejm prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia AT luytengrepm prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia AT verhoevenvirginiejm prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia AT klavercarolinecw prevalenceofmyopicmacularfeaturesindutchindividualsofeuropeanancestrywithhighmyopia |